Table 1 Search strategy as applied in MEDLINE

1

Anesthetics, Local/or local anaesthetic.mp.

2

Anesthetics, Local/or Anesthesia, Local/or Local anaesthesia.mp.

3

Anesthetics/or Anesthesia/or anaesthesia.mp. or Anesthetics, Local/or Anesthesia, Local/

4

anesthesia.mp.

5

anaesthetic.mp.

6

amides.mp. or Amides/

7

(“Huneke neural therapy” or “Neural therapy of Huneke” or benzocaine or bensokain or “Aminobenzoic Acid” or “Aminobenzoate” or bupivacain* or buvacaina or sensorcaine or marcain* or svedocain* or levobupivacaine or carticain* or articain* or dibucaine or cinchocaine or Cincain or Nupercain* or Sovcaine or etidocaine or duranest or “W19053” or “W 19053” or “W-19053” or Lidocaine or Lignocaine or Octocaine or Xylesthesin or Xylocaine or Dalcaine or Xylocitin or Xyloneural or Mepivacain* or Carbocaine or Polocaine or isocaine or isogaine or Scandicain* or prilocaine or Propitocaine or Tetracaine or Tetrakain or Amethocaine or Dicaine or Pantocaine or Pontocaine or Trimecaine or Mesocaine or ropivacaine).mp. [mp = title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier]

8

1 or 2 or 3 or 4 or 5 or 6 or 7

9

(incision or port* or (surg* and wound)).mp. [mp = title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier]

10

acetabular.mp.

11

infiltration.mp.

12

wound infiltration.mp.

13

wound catheter.mp.

14

peri-articular.mp.

15

periarticular.mp.

16

intraarticular.mp.

17

intra-articular.mp.

18

9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17

19

Arthroplasty, Replacement, Knee/or Arthroplasty, Replacement, Hip/

20

exp Arthroplasty, Replacement, Hip/or exp Hip Prosthesis/ or hip replacement.mp.

21

exp Arthroplasty, Replacement, Knee/or exp Knee Prosthesis/or knee replacement.mp.

22

knee prosthesis.mp. or exp Knee Prosthesis/

23

hip prosthesis.mp. or exp Hip Prosthesis/

24

total hip.tw.

25

total knee.tw.

26

Orthopedic Procedures/ or orthopaedic surgery.mp.

27

19 or 20 or 21 or 22 or 23 or 24 or 25 or 26

28

8 and 18 and 27