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Table 4 Sensitivity analysis of relationship between frailty index and falls for the whole group and age subgroups

From: Frailty index of deficit accumulation and falls: data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort

Sensitivity analysis n (%) Age-adjusted models Fully-adjusted models
OR (95% CI)a P-value AUCb OR (95% CI) P-value AUC
Any falls at baseline and during the 3-year follow-up c
  Baseline falls 1483 (37.51) 1.03 (1.03-1.04) <0.001 0.61 1.04 (1.03-1.04) <0.001 0.62
  Women < 65 years 540 (39.16) 1.04 (1.03-1.05) <0.001 0.64 1.04 (1.03-1.05) <0.001 0.64
  Women ≥ 65 years 943 (36.62) 1.03 (1.02-1.04) <0.001 0.61 1.03 (1.03-1.04) <0.001 0.62
  New incident falls d 1204 (51.43) 1.02 (1.02-1.03) <0.001 0.59 1.02 (1.02-1.03) <0.001 0.60
  Women < 65 years 384 (47.64) 1.02 (1.00-1.03) 0.015 0.56 1.02 (1.00-1.03) 0.018 0.58
  Women ≥ 65 years 820 (53.42) 1.02 (1.02-1.03) <0.001 0.61 1.03 (1.02-1.04) <0.001 0.61
  Recurrence of falls e 1135 (81.54) 1.04 (1.03-1.05) <0.001 0.64 1.04 (1.03-1.06) <0.001 0.64
  Women < 65 years 419 (80.58) 1.05 (1.03-1.07) <0.001 0.66 1.06 (1.03-1.08) <0.001 0.68
  Women ≥ 65 years 716 (82.11) 1.04 (1.02-1.05) <0.001 0.63 1.04 (1.02-1.05) <0.001 0.66
Analysis with multiple imputation for missing data f 1317 (33.05)g 1.03 (1.03-1.04) <0.001 0.61 1.02 (1.02-1.03) <0.001 0.69
  Women < 65 years 448 (32.35)g 1.03 (1.02-1.04) <0.001 0.60 1.02 (1.01-1.03) 0.004 0.72
  Women ≥ 65 years 869 (33.42)g 1.03 (1.03-1.04) <0.001 0.62 1.02 (1.02-1.03) <0.001 0.68
  1. aOR: odds ratio; CI: confidence interval; All statistics measured a change of 0.01 on the frailty index.
  2. bAUC: areas under the receiver operating characteristic curves.
  3. cAnalyses adjusted for age, BMI, smoking, drinking, and education.
  4. dDefined as women had any falls during the follow-up but without baseline falls.
  5. eDefined as women had any falls during the follow-up and with baseline falls.
  6. fFor any falls during the third year of follow-up; Analyses adjusted for age, BMI, smoking, drinking, education, and baseline falls.
  7. gNumbers obtained after 10 multiple imputation.