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Table 3 Severe infections according to immunoglobulin subtype and levels

From: The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease

 

Normal immunoglobulin levels

Low immunoglobulin levels

IgG

≥6 g/L

<6 g/L

Patients affected

45/115 (39%)

26/62 (42%)

IgM

≥0.4 g/L

<0.4 g/L

Patients affected

32/87 (37%)

39/90 (43%)

IgA

≥0.8 g/L

<0.8 g/L

Patients affected

56/137 (41%)

15/40 (38%)

  1. The number and proportion of patients suffering severe infections according immunoglobulin subtype (IgG, IgM and IgA) and immunoglobulin level are presented. There is no difference in the proportion of patients affected by infection when comparing IgG levels ≥6 g/L and <6 g/L (p = 0.750); IgM levels ≥0.4 g/L and <0.4 g/L (p = 0.6) and IgA levels ≥0.8 g/L and <0.8 g/L (p = 0.855).