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Table 3 Severe infections according to immunoglobulin subtype and levels

From: The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease

  Normal immunoglobulin levels Low immunoglobulin levels
IgG ≥6 g/L <6 g/L
Patients affected 45/115 (39%) 26/62 (42%)
IgM ≥0.4 g/L <0.4 g/L
Patients affected 32/87 (37%) 39/90 (43%)
IgA ≥0.8 g/L <0.8 g/L
Patients affected 56/137 (41%) 15/40 (38%)
  1. The number and proportion of patients suffering severe infections according immunoglobulin subtype (IgG, IgM and IgA) and immunoglobulin level are presented. There is no difference in the proportion of patients affected by infection when comparing IgG levels ≥6 g/L and <6 g/L (p = 0.750); IgM levels ≥0.4 g/L and <0.4 g/L (p = 0.6) and IgA levels ≥0.8 g/L and <0.8 g/L (p = 0.855).