The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease

Table 2 Frequency and severity of low immunoglobulin levels

	IgG				IgM <0.4 g/L	IgA <0.8 g/L
	< 6 g/L	Mild	Moderate	Severe
	< 6 g/L	5-5.9 g/L	3-4.9 g/L	< 3 g/L
Baseline hypogammaglobulinaemia	18 (13%)	6 (5%)	9 (6%)	3 (2%)	14 (10%)	14 (10%)
Hypogammaglobulinaemia	61 (34%)	18 (10%)	36 (20%)	7 (4%)	90 (51%)	40 (23%)

Baseline hypogammaglobulinaemia (N = 136): total number and proportion in parentheses of patients with low immunoglobulin levels at time of first rituximab.
Hypogammaglobulinaemia (N = 177): total number and proportion in parentheses of patients with low immunoglobulin levels following rituximab for at least three consecutive months at some point during follow-up.

ISSN: 1471-2474