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Table 1 Infusion schedule

From: Safety of infusing rituximab at a more rapid rate in patients with rheumatoid arthritis: results from the RATE-RA study

Time (min)

Infusion rate

Dose in 30 minutes

Cumulative dose

 

(mg/h)

(mL/h)

(mg)

(mg)

Infusion 1

0-30

50

12.5

25

25

31-60

100

25

50

75

61-90

150

37.5

75

150

91-120

200

50

100

250

121-150

250

62.5

125

375

151-180

300

75

150

525

181-210

350

87.5

175

700

211-240

400

100

200

900

241-255

400

100

200

1000

Infusion 2, 3 and 4

0-30

250

62.5

125

125

31-60

600

150

300

425

61-90

600

150

300

725

91 ≈ 120

600

150

275

1000

  1. The total estimated time to complete a 1000-mg dose at Infusion 1 is 4 hours, 15 minutes (4.25 hours) with 8 infusion rate changes. The total estimated time to complete a 1000-mg dose (1000 mg diluted in 250 mL of normal saline or D5W) at Infusion 2, 3 and 4 is approximately 2 hours with 1 infusion rate change.