|
Time (min)
|
Infusion rate
|
Dose in 30 minutes
|
Cumulative dose
|
|---|
| |
(mg/h)
|
(mL/h)
|
(mg)
|
(mg)
|
|---|
|
Infusion 1
|
|
0-30
|
50
|
12.5
|
25
|
25
|
|
31-60
|
100
|
25
|
50
|
75
|
|
61-90
|
150
|
37.5
|
75
|
150
|
|
91-120
|
200
|
50
|
100
|
250
|
|
121-150
|
250
|
62.5
|
125
|
375
|
|
151-180
|
300
|
75
|
150
|
525
|
|
181-210
|
350
|
87.5
|
175
|
700
|
|
211-240
|
400
|
100
|
200
|
900
|
|
241-255
|
400
|
100
|
200
|
1000
|
|
Infusion 2, 3 and 4
|
|
0-30
|
250
|
62.5
|
125
|
125
|
|
31-60
|
600
|
150
|
300
|
425
|
|
61-90
|
600
|
150
|
300
|
725
|
|
91 ≈ 120
|
600
|
150
|
275
|
1000
|
- The total estimated time to complete a 1000-mg dose at Infusion 1 is 4 hours, 15 minutes (4.25 hours) with 8 infusion rate changes. The total estimated time to complete a 1000-mg dose (1000 mg diluted in 250 mL of normal saline or D5W) at Infusion 2, 3 and 4 is approximately 2 hours with 1 infusion rate change.
