An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

Table 5 Association of FN-1 rs6725958 and rs940739 polymorphisms among different grade OA cases and controls

Genetic risk factor	Genotype	Cases	Model	K/L score^$
Genetic risk factor	Genotype	Cases	Model	K/L	Adjusted OR (95% CI)^#	p
rs6725958
	CC	233	AA/CC	2	1.10 (0.74-1.65)	0.628
	CA	489	AA/CC	3	0.81 (0.49-1.35)	0.418
	AA	206	AA/CC	4	2.11 (1.45-3.06)	< 0.001
			CA/CC	2	1.14 (0.83-1.55)	0.427
			CA/CC	3	0.54 (0.36-0.82)	0.003
			CA/CC	4	1.58 (1.16-2.16)	0.004
rs940739
	AA	550	TT/AA	2	1.12 (0.59-2.14)	0.729
	AT	337	TT/AA	3	1.37 (0.59-3.18)	0.465
	TT	41	TT/AA	4	1.15 (0.59-2.24)	0.668
			TA/AA	2	0.96 (0.71-1.30)	0.801
			TA/AA	3	1.22 (0.82-1.18)	0.339
			TA/AA	4	2.07 (1.59-2.69)	< 0.001

^$Grade 0, 1 as a reference category; OA cases = study 1 + study 2; ^#Data have been adjusted by gender, age and BMI.

ISSN: 1471-2474