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Table 5 Association of FN-1 rs6725958 and rs940739 polymorphisms among different grade OA cases and controls

From: An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

Genetic risk factor Genotype Cases Model K/L score$
K/L Adjusted OR (95% CI)# p
rs6725958       
  CC 233 AA/CC 2 1.10 (0.74-1.65) 0.628
  CA 489 AA/CC 3 0.81 (0.49-1.35) 0.418
  AA 206 AA/CC 4 2.11 (1.45-3.06) < 0.001
    CA/CC 2 1.14 (0.83-1.55) 0.427
    CA/CC 3 0.54 (0.36-0.82) 0.003
    CA/CC 4 1.58 (1.16-2.16) 0.004
rs940739       
  AA 550 TT/AA 2 1.12 (0.59-2.14) 0.729
  AT 337 TT/AA 3 1.37 (0.59-3.18) 0.465
  TT 41 TT/AA 4 1.15 (0.59-2.24) 0.668
    TA/AA 2 0.96 (0.71-1.30) 0.801
    TA/AA 3 1.22 (0.82-1.18) 0.339
    TA/AA 4 2.07 (1.59-2.69) < 0.001
  1. $Grade 0, 1 as a reference category; OA cases = study 1 + study 2; #Data have been adjusted by gender, age and BMI.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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