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Table 4 Genotype distributions of ITGAV polymorphisms and their association with OA risk

From: An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

SNP   Study 1   Study 2   Study 1 + Study 2  
Case Control OR (95% CI)# Case Control OR (95% CI)# OR (95% CI)#$ ORMeta I2
rs3911238 GG 294 216 1 381 266 1 1 1  
  GC 99 89 0.84 (0.59-1.82) 129 101 0.86 (0.63-1.18) 0.84 (0.67-1.06) 0.85 (0.67-1.08) 0
  CC 10 9 0.92 (0.36-2.40) 15 12 0.92 (0.42-2.03) 0.93 (0.51-1.72) 0.92 (0.50-1.68) 0
  G 0.85 0.83 1 0.85 0.84 1 1 1  
  C 0.15 0.17 0.87 (0.65-1.17) 0.15 0.16 0.89 (0.69-1.16) 0.88 (0.73-1.07) 0.88 (0.73-1.07) 0
rs10174098 AA 285 209 1 351 240 1 1 1  
  AG 104 96 0.74 (0.52-1.04) 154 129 0.77 (0.57-1.03) 0.77 (0.62-0.96) 0.76 (0.60-0.95) 0
  GG 14 9 1.27 (0.53-3.05) 20 10 1.19 (0.53-2.64) 1.22 (0.68-2.20) 1.23 (0.68-2.22) 0
  A 0.84 0.82 1 0.82 0.80 1 1 1  
  G 0.16 0.18 0.86 (0.65-1.14) 0.18 0.20 0.87 (0.68-1.11) 0.88 (0.73-1.05) 0.87 (0.72-1.04) 0
rs3738919 CC 366 273 1 468 344 1 1 1  
  CA 35 37 0.66 (0.39-1.09) 54 44 0.87 (0.56-1.34) 0.77 (0.55-1.06) 0.78 (0.55-1.09) 0
  AA 2 4 0.29 (0.05-1.70) 3 1 2.18 (0.22-21.58) 0.70 (0.19-2.50) 0.69 (0.10-4.90) 46.58
  C 0.95 0.93 1 0.94 0.94 1 1 1  
  A 0.05 0.07 0.60 (0.38-0.95) 0.06 0.06 0.93 (0.62-1.40) 0.77 (0.57-1.04) 0.76 (0.49-1.16) 49.44
rs1448427 AA 267 196 1 325 234 1 1 1  
  AG 123 108 0.90 (0.37-2.18) 179 129 1.00 (0.49-2.03) 0.91 (0.74-1.13) 0.96 (0.55-1.67) 0
  GG 13 10 0.79 (0.57-1.10) 21 16 1.00 (0.75-1.34) 0.96 (0.55-1.66) 0.90 (0.72-1.13) 11.32
  A 0.82 0.80 1 0.79 0.79 1 1 1  
  G 0.18 0.20 0.85 (0.65-1.12) 0.21 0.21 1.00 (0.79-1.27) 0.94 (0.79-1.12) 0.93 (0.78-1.11) 0
  1. #Data have been adjusted by gender, age and BMI; $Simply pooled OR.