An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

Table 4 Genotype distributions of ITGAV polymorphisms and their association with OA risk

SNP		Study 1			Study 2			Study 1 + Study 2
SNP		Case	Control	OR (95% CI)^#	Case	Control	OR (95% CI)^#	OR (95% CI)^#$	OR_Meta	I²
rs3911238	GG	294	216	1	381	266	1	1	1
	GC	99	89	0.84 (0.59-1.82)	129	101	0.86 (0.63-1.18)	0.84 (0.67-1.06)	0.85 (0.67-1.08)	0
	CC	10	9	0.92 (0.36-2.40)	15	12	0.92 (0.42-2.03)	0.93 (0.51-1.72)	0.92 (0.50-1.68)	0
	G	0.85	0.83	1	0.85	0.84	1	1	1
	C	0.15	0.17	0.87 (0.65-1.17)	0.15	0.16	0.89 (0.69-1.16)	0.88 (0.73-1.07)	0.88 (0.73-1.07)	0
rs10174098	AA	285	209	1	351	240	1	1	1
	AG	104	96	0.74 (0.52-1.04)	154	129	0.77 (0.57-1.03)	0.77 (0.62-0.96)	0.76 (0.60-0.95)	0
	GG	14	9	1.27 (0.53-3.05)	20	10	1.19 (0.53-2.64)	1.22 (0.68-2.20)	1.23 (0.68-2.22)	0
	A	0.84	0.82	1	0.82	0.80	1	1	1
	G	0.16	0.18	0.86 (0.65-1.14)	0.18	0.20	0.87 (0.68-1.11)	0.88 (0.73-1.05)	0.87 (0.72-1.04)	0
rs3738919	CC	366	273	1	468	344	1	1	1
	CA	35	37	0.66 (0.39-1.09)	54	44	0.87 (0.56-1.34)	0.77 (0.55-1.06)	0.78 (0.55-1.09)	0
	AA	2	4	0.29 (0.05-1.70)	3	1	2.18 (0.22-21.58)	0.70 (0.19-2.50)	0.69 (0.10-4.90)	46.58
	C	0.95	0.93	1	0.94	0.94	1	1	1
	A	0.05	0.07	0.60 (0.38-0.95)	0.06	0.06	0.93 (0.62-1.40)	0.77 (0.57-1.04)	0.76 (0.49-1.16)	49.44
rs1448427	AA	267	196	1	325	234	1	1	1
	AG	123	108	0.90 (0.37-2.18)	179	129	1.00 (0.49-2.03)	0.91 (0.74-1.13)	0.96 (0.55-1.67)	0
	GG	13	10	0.79 (0.57-1.10)	21	16	1.00 (0.75-1.34)	0.96 (0.55-1.66)	0.90 (0.72-1.13)	11.32
	A	0.82	0.80	1	0.79	0.79	1	1	1
	G	0.18	0.20	0.85 (0.65-1.12)	0.21	0.21	1.00 (0.79-1.27)	0.94 (0.79-1.12)	0.93 (0.78-1.11)	0

ISSN: 1471-2474