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Table 3 Association analyses for FN-1 SNPs with OA in the combined analyses of both study groups

From: An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

SNP

 

Case

Control

Simply pooled OR (95% CI)#

p

ORMeta(95% CI)#

I2

rs10202709

GG

864

651

1

 

1

 
 

GA

61

40

1.13 (0.74-1.72)

0.583

1.15 (0.63-2.10)

47.99

 

AA

3

2

1.15 (0.19-711)

0.881

1.13 (0.18-7.09)

0

 

G

0.96

0.97

1

 

1

 
 

A

0.04

0.03

1.24 (0.76-1.67)

0.565

1.16 (0.72-1.87)

23.50

rs6725958

CC

233

213

1

 

1

 
 

CA

489

355

1.17 (0.92-1.48)

0.201

1.08 (0.76-1.53)

0

 

AA

206

125

1.39 (1.03-1.88)

0.030

1.40 (1.04-1.89)

0

 

C

0.52

0.56

1

 

1

 
 

A

0.48

0.44

1.17 (1.01-1.35)

0.033

1.17 (1.01-1.35)

0

rs940739

AA

550

468

1

 

1

 
 

AT

337

198

1.44 (1.16-1.80)

0.001&

1.46 (1.17-1.83)

0

 

TT

41

27

1.14 (0.68-1.91)

0.624

1.11 (0.67-1.86)

0

 

A

0.77

0.82

1

 

1

 
 

T

0.23

0.18

1.28 (1.07-1.53)

0.008

1.28 (1.07-1.54)

0

rs2304573

GG

529

385

1

 

1

 
 

GA

335

256

0.97 (0.78-1.20)

0.754

0.97 (0.78-1.21)

0

 

AA

64

52

0.93 (0.62-1.38)

0.701

0.94 (0.63-1.40)

0

 

G

0.75

0.74

1

 

1

 
 

A

0.25

0.26

0.96 (0.82-1.13)

0.647

0.97 (0.82-1.14)

0

rs11651

AA

441

305

1

 

1

 
 

AG

383

294

0.90 (0.73-1.12)

0.359

0.91 (0.73-1.13)

0

 

GG

104

94

0.78 (0.57-1.08)

0.138

0.78 (0.57-1.08)

0

 

A

0.68

0.65

1

 

1

 
 

G

0.32

0.35

0.88 (0.76-1.03)

0.112

0.89 (0.76-1.04)

0

rs3796123

TT

768

577

1

 

1

 
 

TA

148

112

0.95 (0.72-1.25)

0.691

0.96 (0.73-1.27)

0

 

AA

12

4

2.14 (0.67-6.87)

0.202

2.14 (0.38-12.14)

44.49

 

T

0.91

0.91

1

 

1

 
 

A

0.09

0.09

1.03 (0.80-1.33)

0.818

1.04 (0.75-1.44)

36.03

  1. #Data have been adjusted by gender, age and BMI; &p-values were based upon Bonferroni’s method.