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Table 2 Genotype distributions of FN-1 polymorphisms and their association with OA risk

From: An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

SNP

 

Study 1

 

Study 2

 

Case

Control

Adjusted OR (95% CI)#

Case

Control

Adjusted OR (95% CI)#

rs10202709

GG

376

300

1

488

351

1

 

GA

26

13

1.64 (0.81-3.33)

35

27

0.88 (0.52-1.52)

 

AA

1

1

1.00 (0.06-16.72)

2

1

1.24 (0.11-14.25)

 

G

0.96

0.98

1

0.96

0.96

1

 

A

0.04

0.02

1.54 (0.80-2.97)

0.04

0.04

0.94 (0.55-1.52)

rs6725958

CC

113

102

1

120

111

1

 

CA

200

158

1.08 (0.76-1.54)

289

197

1.25 (0.90-1.72)

 

AA

90

54

1.44 (0.92-2.25)

116

71

1.37 (0.92-2.05)

 

C

0.53

0.58

1

0.50

0.55

1

 

A

0.47

0.42

1.18 (0.95-1.47)

0.50

0.45

1.16 (0.96-1.41)

rs940739

AA

240

208

1

310

260

1

 

AT

146

94

1.44 (1.03-2.01)*

191

104

1.48 (1.10-1.99)*

 

TT

17

12

1.07 (0.49-2.36)

24

15

1.15 (0.58-2.28)

 

A

0.78

0.81

1

0.77

0.82

1

 

T

0.22

0.19

1.26 (0.96-1.65)

0.23

0.18

1.30 (1.02-1.65)*

rs2304573

GG

227

173

1

302

212

1

 

GA

146

119

0.95 (0.68-1.31)

189

137

0.99 (0.74-1.33)

 

AA

30

22

1.15 (0.63-2.10)

34

30

0.80 (0.47-1.36)

 

G

0.74

0.74

1

0.75

0.74

1

 

A

0.26

0.26

1.02 (0.79-1.30)

0.25

0.26

0.93 (0.75-1.17)

rs11651

AA

190

138

1

251

167

1

 

AG

170

130

0.93 (0.67-1.29)

213

164

0.89 (0.66-1.19)

 

GG

43

46

0.71 (0.44-1.16)

61

48

0.85 (0.55-1.31)

 

A

0.68

0.65

1

0.68

0.66

1

 

G

0.32

0.35

0.86 (0.68-1.08)

0.32

0.34

0.91 (0.74-1.11)

rs3796123

TT

338

259

1

430

318

1

 

TA

61

52

0.83 (0.54-1.27)

87

60

1.07 (0.74-1.54)

 

AA

4

3

1.02 (0.22-4.68)

8

1

6.17 (0.73-52.51)

 

T

0.91

0.91

1

0.90

0.92

1

 

A

0.09

0.09

0.87 (0.59-1.27)

0.10

0.08

1.21 (0.86-1.70)

  1. * p < 0.05; #Data have been adjusted by gender, age and BMI.