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Table 2 Clinical Study Characteristics

From: Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review

Study

Type

n

Initial AVN class

AVN etiology (# of hips)

Treatment protocol

Hernigou et al. [35]

Case series

534

Ficat 1-2

steroid (101), ethanol (150), sickle cell (166), not specified (117)

Concentrated BMMNC

Wang et al. [9]

Case series

50

ARCO 1-2

steroid (25), ethanol (19), idiopathic (6)

Concentrated BMMNC

Gangji et al. [2]

nRCT

24

ARCO 1-2

steroid (20), ethanol (2), idiopathic (2)

Concentrated BMMNC

Sen et al. [14]

RCT

51

ARCO 1-2

trauma (17), steroid (20), ethanol 8), idiopathic (2), pregnancy (2), Cushings (2)

Concentrated BMMNC

Zhao et al. [8]

RCT

97

ARCO 1C-2C

trauma (20), steroid (24), ethanol (19), Caisson (11), idiopathic (30) (some patients had more than one etiology)

Cultured BMMNC

  1. BMMNC = bone marrow mononuclear cells, n = number of hips, ARCO = Association Research Circulation Osseous classification, nRCT = non randomized control trial, RCT = randomized control trial.