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Table 1 Preclinical study characteristics and results

From: Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review

Study Animal model Stem cell therapy Results
    Histology Imaging
    Bone formation Angiogenesis X-ray SPECT CT MR
Wen et al. [30] Rabbit BMMNC-MSC +ve +ve* -- -- +ve +ve
Sun et al. [6] Rabbit BMMNC +ve* +ve* -- -- +ve* --
Yan et al. [12] Dog BMMNC-MSC +ve* -- -- -- -- --
Feitosa et al. [4] Sheep hIDPSC, BMMNC-MSC +ve -- -- -- -- --
Abudusaimi et al. [10] Rabbit ADSC +ve -- -- -- +ve* --
Aimaiti et al. [34] Rabbit ADSC +ve +ve -- -- +ve* --
Song et al. [17] Rabbit PBSC +ve +ve* -- -- -- --
Sun et al. [31] Rabbit EPC +ve* +ve* -- -- -- --
Hang et al. [11] Dog BMMNC-MSC +ve* +ve* +ve +ve -- --
Wen et al. [33] Rabbit BMMNC-MSC +ve -- -- -- -- --
Xie et al. [32] Rabbit cBMMNC +ve* +ve* -- -- +ve* --
  1. BMMNC-MSC = mesenchymal stem cells obtained post bone marrow mononuclear cell culture, hIDPSC = human immature dental pulp stem cells, ADSC = adipose derived stem cells, PBSC = peripheral blood stem cells, EPC = endothelial progenitor cells, cBMMNC = cryoperserved bone marrow mononuclear cells, +ve = positive effect compared to controls, −ve = negative effect compared to controls, -- = not measured, * = statistically significant (p < 0.05).