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Table 2 Secular trend of WOMAC function score in two studies with interaction between study and time

From: Comparing the functional impact of knee replacements in two cohorts

 

Annual WOMAC function change (95% CI)*

P value

SxOA subjects

Visit, year

 

−0.64 (−0.88, −0.39)

<.0001

Study

MOST

3.15 (2.14, 4.16)

<.0001

Study

OAI

1.0 (referent)

 

Visit* study

MOST

−0.39 (−0.70, −0.08)

0.01

Visit* study

OAI

1.0 (referent)

 

SxOA subjects, excluding those with TKR

Visit, year

 

−0.50 (−0.726 -0.23)

0.0008

Study

MOST

3.24 (2.20, 4.29)

<.0001

Study

OAI

1.0 (referent)

 

Visit* study

MOST

−0.08 (−0.41, 0.25)

0.64

Visit* study

OAI

1.0 (referent)

 
  1. *Adjusted for age, sex, BMI, race, clinical site, CES-D, co-morbidity, number of painful joints in lower limbs other than knees, and number of knees with symptomatic OA.