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Table 2 Secular trend of WOMAC function score in two studies with interaction between study and time

From: Comparing the functional impact of knee replacements in two cohorts

  Annual WOMAC function change (95% CI)* P value
SxOA subjects
Visit, year   −0.64 (−0.88, −0.39) <.0001
Study MOST 3.15 (2.14, 4.16) <.0001
Study OAI 1.0 (referent)  
Visit* study MOST −0.39 (−0.70, −0.08) 0.01
Visit* study OAI 1.0 (referent)  
SxOA subjects, excluding those with TKR
Visit, year   −0.50 (−0.726 -0.23) 0.0008
Study MOST 3.24 (2.20, 4.29) <.0001
Study OAI 1.0 (referent)  
Visit* study MOST −0.08 (−0.41, 0.25) 0.64
Visit* study OAI 1.0 (referent)  
  1. *Adjusted for age, sex, BMI, race, clinical site, CES-D, co-morbidity, number of painful joints in lower limbs other than knees, and number of knees with symptomatic OA.