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Table 3 Association of LRP5 genotypes with BMD a

From: Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Polymorphisms
  Val667Met Ala1330Val
  GG GA + AA P CC CT + TT P
Parameter n = 498 n = 68 value b, e, F n = 452 n = 114 value b
Osteopenia c 87.5 12.5   77.6 22.4  
+osteoporosis (%) d       
Normals (%) 88.7 11.3 0.373 83.1 16.9 0.066
fractured women (%) 89.1 10.9   85.5 14.5  
Non fractured women (%) 87.9 12.1 0.499 79.3 20.7 0.182
BMD spine (g/cm2) 0.869 ± 0.144 0.854 ± 0.134 0.438 0.873 ± 0.145 0.841 ± 0.134 0.072
Tscore spine −1.085 ± 1.339 −1.327 ± 1.305 0.170 −1.044 ± 1.338 −1.388 ± 1.297 0.047*
BMD right hip (g/cm2) 0.880 ± 0.127 0.872 ± 0.136 0.62 0.882 ± 0.127 0.867 ± 0.131 0.359
Tscore right hip −0.451 ± 1.066 −0.648 ± 1.225 0.176 −0.433 ± 1.060 −0.639 ± 1.183 0.164
BMD left hip (g/cm2) 0.877 ± 0.129 0.870 ± 0.127 0.685 0.879 ± 0.129 0.865 ± 0.127 0.448
Tscore right hip −0.514 ± 1.019 −0.635 ± 1.131 0.380 −0.499 ± 0.999 −0.645 ± 1.155 0.350
BMD total hip 0.857 ± 0.120 0.851 ± 0.132 0.823 0.859 ± 0.120 0.847 ± 0.126 0.430
Tscore total hip −0.652 ± 1.001 −0.801 ± 1.182 0.522 −0.635 ± 0.994 −0.807 ± 1.135 0.232
  1. aContinuous variables (BMD values) are expressed as mean standard deviation, and categorical variables (osteopenia, osteoporosis, presence osteoporotical fracture) are expressed as percentages (%).
  2. bBased on Student t test for continuous variables.
  3. cWorld Health Organization definition: 1 standard deviatio ≥ T score ≤ 2.5 standard deviation (29).
  4. dWorld Health Organization definition: T score ≤ 2.5 standard deviation (29).
  5. eBased on χ2 test between two groups OP + O and Normales.
  6. fBased on χ2 test between two groups fractured and non fractured women.
  7. *p≤ 0,05 significant in bold character.