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Table 3 Association of LRP5 genotypes with BMD a

From: Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Polymorphisms

 

Val667Met

Ala1330Val

 

GG

GA + AA

P

CC

CT + TT

P

Parameter

n = 498

n = 68

value b, e, F

n = 452

n = 114

value b

Osteopenia c

87.5

12.5

 

77.6

22.4

 

+osteoporosis (%) d

      

Normals (%)

88.7

11.3

0.373

83.1

16.9

0.066

fractured women (%)

89.1

10.9

 

85.5

14.5

 

Non fractured women (%)

87.9

12.1

0.499

79.3

20.7

0.182

BMD spine (g/cm2)

0.869 ± 0.144

0.854 ± 0.134

0.438

0.873 ± 0.145

0.841 ± 0.134

0.072

Tscore spine

−1.085 ± 1.339

−1.327 ± 1.305

0.170

−1.044 ± 1.338

−1.388 ± 1.297

0.047*

BMD right hip (g/cm2)

0.880 ± 0.127

0.872 ± 0.136

0.62

0.882 ± 0.127

0.867 ± 0.131

0.359

Tscore right hip

−0.451 ± 1.066

−0.648 ± 1.225

0.176

−0.433 ± 1.060

−0.639 ± 1.183

0.164

BMD left hip (g/cm2)

0.877 ± 0.129

0.870 ± 0.127

0.685

0.879 ± 0.129

0.865 ± 0.127

0.448

Tscore right hip

−0.514 ± 1.019

−0.635 ± 1.131

0.380

−0.499 ± 0.999

−0.645 ± 1.155

0.350

BMD total hip

0.857 ± 0.120

0.851 ± 0.132

0.823

0.859 ± 0.120

0.847 ± 0.126

0.430

Tscore total hip

−0.652 ± 1.001

−0.801 ± 1.182

0.522

−0.635 ± 0.994

−0.807 ± 1.135

0.232

  1. aContinuous variables (BMD values) are expressed as mean standard deviation, and categorical variables (osteopenia, osteoporosis, presence osteoporotical fracture) are expressed as percentages (%).
  2. bBased on Student t test for continuous variables.
  3. cWorld Health Organization definition: 1 standard deviatio ≥ T score ≤ 2.5 standard deviation (29).
  4. dWorld Health Organization definition: T score ≤ 2.5 standard deviation (29).
  5. eBased on χ2 test between two groups OP + O and Normales.
  6. fBased on χ2 test between two groups fractured and non fractured women.
  7. *p≤ 0,05 significant in bold character.