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Table 3 Characteristics of the 6 studies included in the literature review

From: Cardiovascular case fatality in rheumatoid arthritis is decreasing; first prospective analysis of a current low disease activity rheumatoid arthritis cohort and review of the literature

Reference

Country

Enrolment period

Mean follow up (years)

Sample type

Inception cohort

RA definition

% female

Mean age at entry

Previous CVD excluded

CVD included

Outcome ascertainment

N

Person-years at risk

CV events (n)

CV events/ 1000 person-years

Fatal CV events (%)

Del Rincon, 2001 [13]

USA

1996

0.9

Clinic based

No

ACR 1987

62.3

56*

Yes

MI, CVA, CV death

Medical record

236

204

7

34.3

28.6

Assous, 2007 [23]

France

1998-1999

5.4

Clinic based

No

ACR 1987

83.8

55

Yes

MI, CVA, CV death

Medical record

239

NAV

17

13

52.9

Solomon, 2006 [23]

USA

1999-2003

2.8

Population based

No

ICD code

71.1

NAV

No

MI, CVA, CV death

ICD code

25,385

70,612

1,042

14.8

41.2

Peters, 2009 [24]

Netherlands

2001-2002

2.7

Clinic based

No

ACR 1987

65

63

Yes

Coronary disease, CVA, CV and sudden death

Medical record

272

729

19

26.1

12.9**

Meek, 2013*** [19]

Netherlands

2009-2011

2.9

Clinic based

No

Clinical diagnosis

72.3

59

Yes

Coronary disease, CVA, CV and sudden death

Medical record

480

1380

29

21

6.9

Maradit-Kremers, 2005 [9]

USA

1955-1995

14.7

Population based

Yes

ACR 1987

73

58

Yes

MI, CABG, PTCA, AP, CV and sudden death

Medical record

603

8,672

109

13.0

23.8

Holmqvist, 2010 [25]

Sweden

1995-2006

4.1

Population based

Yes

ACR 1987

71.0

56.9

Yes

MI, AP, CABG, PTCA, CV death

Hospital discharge register

7,469

33,436

341

10.2

11.1

  1. Studies are placed in order of cohort type (non-inception vs inception) and enrolment period. RA: rheumatoid arthritis; CVD: cardiovascular disease; MI: myocardial infarction; CVA: cerebrovascular incident; CV: cardiovascular; CABG: coronary artery bypass graft; PTCA: percutaneous transluminal coronary angioplasty; AP: angina pectoris; NAV: not available. * Median. ** non-published data received from the authors. ***data from the ACT-CVD cohort presented in htis article.