Figure 1From: Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model Muscle tissue of the gastrocnemius (A) and soleus (inset, A) muscles. The animals had been subjected to muscle overuse coupled with local injections with NaCl. The muscle tissue shows a normal organization, and very occasional presence of necrotic muscle fibers (middle in inset). Bar = 50 μm. Muscle tissue of gastrocnemius muscles from two animals subjected to muscle overuse coupled with local injections with SP + C + Th; non-exercised side (B), exercised side (C). There is a variability in muscle fiber appearance, a very marked inflammatory infiltrate (to the right, B) and necrotic muscle fibers (arrowheads, C). There is a presence of very small muscle fibers in the inflammatory infiltrate (arrows, B). Bars = 50 μm.Back to article page