Figure 2From: Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis Osteocyte size and circularity. Quantification of the relative size and circularity of (A, B) lacunae containing viable osteocytes and (C, D) empty lacunae in cortical bone from wild-type (WT) and Cx43 conditional knockout (cKO) mice following three weeks of normal loading conditions (Control) or mechanical unloading via hindlimb suspension (Suspended). Lacunae were quantified within a 2400 μm linear region of the mid-diaphysis of the femur. Mean ± SE. * indicates a significant difference (p < 0.05) between Control and Suspended within a genotype, while †indicates a significant difference (p < 0.05) between WT and cKO within a loading condition. n = 5/group.Back to article page