Primary outcome | Data collection instrument (unit) | Collection time-point | ||
---|---|---|---|---|
 |  | Baseline | Post (days) | Post (months) |
Function in daily living | KOOS | Pre | 14 | 3,6,12 |
Secondary outcome | Â | Â | Â | Â |
KOOS - 4 subscales | Â | Â | Â | Â |
 Pain | KOOS | Pre | 14 | 3,6,12 |
 Symptoms | KOOS | Pre | 14 | 3,6,12 |
 Sport and recreation | KOOS | Pre | 14 | 3,6,12 |
 Quality of life | KOOS | Pre | 14 | 3,6,12 |
Questionnaire | Â | Â | Â | Â |
 Global perceived effect | GPE |  |  | 3,6,12 |
Bilateral physical Performance | Â | Â | Â | Â |
 Knee range of motion (KneeROM) | Goniometer (°) | Pre | 3,14 | 3,6 |
 30-s chair-stand test (30s CRT) | (Number) | Pre | 3,14 | 3,6 |
 20-m self- and fast-paced walk test (20mWT) | Stopwatch (s) | Pre | 3,14 | 3,6 |
 Timed up-and-go test (TUG) | Stopwatch (s) | Pre | 3,14 | 3,6 |
Explorative outcomes | Â | Â | Â | Â |
Mechanical muscle function | Â | Â | Â | Â |
 Maximal isometric knee strength (iMVC) | Strain-gauge (Nm) | Pre |  | 3,6 |
 Dynamic leg extension power | (W) | Pre |  | 3,6 |
 Rate of force development (RFD) | (Nm/sec) | Pre |  | 3,6 |
 Surface electromyography (EMG) | Myon (mV) | Pre |  | 3,6 |
 Force steadiness | (Nm) | Pre |  | 3,6 |
Unilateral physical performance | Â | Â | Â | Â |
 30-s single-leg knee bending (30s-KneeBend) | (Number) | Pre |  | 3,6 |
Pain | Â | Â | Â | Â |
 Self-reported use of pain medication | (Quantity) | Pre | 1-14 |  |
 Self-reported pain (VAS) | VAS | Pre | 1-14 |  |
Biopsies | Â | Â | Â | Â |
 Muscle biopsy |  | Prior to applying and removal of the tourniquet |