Figure 6

Changes in extracellular matrix composition determined by histology and IHC. (A) Total proteoglycan content was significantly affected by both treatment and duration in culture. (B) Independent of treatment, collagen type II content was significantly affected by duration in culture and was significantly reduced at day 32 compared to day 8. Bars represent mean (± SEM), bars with the same letter for each pathology are not significantly different from each other, significance set at alpha (p-value) = 0.05, n = 6. Main effects or interactions were evaluated in the AOV table with a predictive F-value (Pr > F).