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Table 6 Teriparatide utilization and fracture-related utilization and costs in the 12 month follow-up period

From: Association of teriparatide adherence and persistence with clinical and economic outcomes in Medicare Part D recipients: a retrospective cohort study

Measure PDC* < 50% PDC 50% ≤80% PDC ≥ 80% Persistent Non-perstistent
  low adherent moderately adherent highly adherent   (60 day gap)
Total Patients, n (%) 168 (75.7%) 15 (6.8%) 39 (17.6%) 43 (19.4%) 179 (80.6%)
Fracture-Related Inpatient Hospitalization      
  Members with Hospitalization, n (%) 18 (10.7%) 1 (6.7%) 2 (5.1%) 2 (4.7%) 19 (10.6%)
  Hospitalizations Per Member** 0.1 (± 0.4) 0.1 (± 0.3) 0.1 (± 0.2) 0. (± 0.2) 0.1 (± 0.4)
0 [0 - 2] 0 [0 - 1] 0 [0 - 1] 0 [0 - 1] 0 [0 - 2]
Fracture-Related Emergency Room Visits      
  Members with Visit, n (%) 31 (18.5%) 1 (6.7%) 3 (7.7%) 3 (6.98%) 32 (17.9%)
  Visits Per Member** 0.2 (± 0.5) 0.1 (± 0.3) 0.1 (± 0.5) 0.1 (± 0.5) 0.2 (± 0.5)
0 [0 - 2] 0 [0 - 1] 0 [0 - 3] 0 [0 - 3] 0 [0 - 2]
Fracture-Related Outpatient Visits      
  Members with Visit, n (%) 160 (95.2%) 15 (100.%) 38 (97.4%) 42 (97.7%) 171 (95.5%)
  Visits Per Member** 4.2 (± 7.96) 4.3 (± 5.14) 3.8 (± 5.48) 3.4 (± 5.21) 4.3 (± 7.83)
  2 [0 - 65] 2 [1 - 17] 2 [0 - 32] 2 [0 - 32] 2 [0 - 65]
Fracture-Related Pharmacy Claims      
  Pain Medications      
   Members with Pharmacy Claim, n (%) 126 (75.0%) 11 (73.33%) 24 (61.54%) 27 (62.79%) 134 (74.86%)
   Pharmacy Claims Per Member** 5.5 (± 7.3) 6.1 (± 10.2) 5.7 (± 8.4) 5.5 (± 8.4) 5.6 (± 7.5)
2 [0 - 43] 2 [0 - 33] 2 [0 - 42] 2 [0 - 42] 2 [0 - 43]
Osteoporosis Medications      
  Members with Pharmacy Claim, n (%) 168 (100.%) 15 (100.%) 39 (100.%) 43 (100.%) 179 (100.%)
  Pharmacy Claims Per Member** † ‡ 4. (± 3.3) 9. (± 1.4) 12.5 (± 2.4) 12.2 (± 2.5) 4.3 (± 3.4)
3 [1 - 16] 9 [7 - 12] 13 [5 - 18] 12 [5 - 18] 3 [1 - 16]
Total Healthcare Cost** † ‡ $4,419 (± $6,018) $9,292 (± $4,396) $12,670 (± $4,963) $12,199 (± $4,932) $4,756 (± $6,099)
$2,710 [$854 - $40,637] $8,111 [$5,850 - $23,884] $11,296 [$9,008 - $36,026] $11,263 [$7,616 - $36,026] $2,765 [$854 - $40,637]
 Inpatient Hospitalization Cost** $1,325 (± $4,988) $830 (± $3,214) $366 (± $2,026) $332 (± $1,930) $1,313 (± $4,913)
$ [$0 - $37,355] $ [$0 - $12,449] $ [$0 - $12,585] $ [$0 - $12,585] $ [$0 - $37,355]
 Emergency Room Visit Cost** $44 (± $132) $9 (± $36) $6 (± $24) $6 (± $23) $42 (± $129)
$0 [$0 - $753] $0 [$0 - $141] $0 [$0 - $128] $0 [$0 - $128] $0 [$0 - $753]
 Outpatient Cost** $767 (± $1,903) $955 (± $1,538) $1,048 (± $3,716) $941 (± $3,545) $802 (± $1,892)
$159 [$0 - $12,380] $220 [$0 - $5,733] $215 [$0 - $23,383] $186 [$0 - $23,383] $176 [$0 - $12,380]
 Osteoporosis Medication Cost** † ‡ $2,068 (± $1,196) $7,420 (± $1,169) $10,810 (± $1,250) $10,516 (± $1,520) $2,391 (± $1,746)
$1,713 [$779 - $5,259] $7,350 [$5,744 - $9,631] $10,969 [$8,811 - $14,910] $10,748 [$6,836 - $14,910] $1,735 [$779 - $9,631]
 Pain Medication Pharmacy Cost** $216 (± $646) $77 (± $172) $440 (± $1,201) $404 (± $1,150) $208 (± $628)
$28 [$0 - $6,071] $11 [$0 - $662] $18 [$0 - $6,276] $14 [$0 - $6,276] $27 [$0 - $6,071]
  1. * Proportion of days covered.
  2. **Mean, standard deviation, median, [range].
  3. † ANOVA pairwise comparison between PDC < 50% and PDC ≥ 80% groups, p < 0.05.
  4. t-test between ‘Persistent’ and ‘Non-Persistent’ (60 Day Gap) groups, p < 0.05.