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Table 6 Teriparatide utilization and fracture-related utilization and costs in the 12 month follow-up period

From: Association of teriparatide adherence and persistence with clinical and economic outcomes in Medicare Part D recipients: a retrospective cohort study

Measure

PDC* < 50%

PDC 50% ≤80%

PDC ≥ 80%

Persistent

Non-perstistent

 

low adherent

moderately adherent

highly adherent

 

(60 day gap)

Total Patients, n (%)

168 (75.7%)

15 (6.8%)

39 (17.6%)

43 (19.4%)

179 (80.6%)

Fracture-Related Inpatient Hospitalization

     

  Members with Hospitalization, n (%)

18 (10.7%)

1 (6.7%)

2 (5.1%)

2 (4.7%)

19 (10.6%)

  Hospitalizations Per Member**

0.1 (± 0.4)

0.1 (± 0.3)

0.1 (± 0.2)

0. (± 0.2)

0.1 (± 0.4)

0 [0 - 2]

0 [0 - 1]

0 [0 - 1]

0 [0 - 1]

0 [0 - 2]

Fracture-Related Emergency Room Visits

     

  Members with Visit, n (%)

31 (18.5%)

1 (6.7%)

3 (7.7%)

3 (6.98%)

32 (17.9%)

  Visits Per Member**

0.2 (± 0.5)

0.1 (± 0.3)

0.1 (± 0.5)

0.1 (± 0.5)

0.2 (± 0.5)

0 [0 - 2]

0 [0 - 1]

0 [0 - 3]

0 [0 - 3]

0 [0 - 2]

Fracture-Related Outpatient Visits

     

  Members with Visit, n (%)

160 (95.2%)

15 (100.%)

38 (97.4%)

42 (97.7%)

171 (95.5%)

  Visits Per Member**

4.2 (± 7.96)

4.3 (± 5.14)

3.8 (± 5.48)

3.4 (± 5.21)

4.3 (± 7.83)

 

2 [0 - 65]

2 [1 - 17]

2 [0 - 32]

2 [0 - 32]

2 [0 - 65]

Fracture-Related Pharmacy Claims

     

  Pain Medications

     

   Members with Pharmacy Claim, n (%)

126 (75.0%)

11 (73.33%)

24 (61.54%)

27 (62.79%)

134 (74.86%)

   Pharmacy Claims Per Member**

5.5 (± 7.3)

6.1 (± 10.2)

5.7 (± 8.4)

5.5 (± 8.4)

5.6 (± 7.5)

2 [0 - 43]

2 [0 - 33]

2 [0 - 42]

2 [0 - 42]

2 [0 - 43]

Osteoporosis Medications

     

  Members with Pharmacy Claim, n (%)

168 (100.%)

15 (100.%)

39 (100.%)

43 (100.%)

179 (100.%)

  Pharmacy Claims Per Member** † ‡

4. (± 3.3)

9. (± 1.4)

12.5 (± 2.4)

12.2 (± 2.5)

4.3 (± 3.4)

3 [1 - 16]

9 [7 - 12]

13 [5 - 18]

12 [5 - 18]

3 [1 - 16]

Total Healthcare Cost** † ‡

$4,419 (± $6,018)

$9,292 (± $4,396)

$12,670 (± $4,963)

$12,199 (± $4,932)

$4,756 (± $6,099)

$2,710 [$854 - $40,637]

$8,111 [$5,850 - $23,884]

$11,296 [$9,008 - $36,026]

$11,263 [$7,616 - $36,026]

$2,765 [$854 - $40,637]

 Inpatient Hospitalization Cost**

$1,325 (± $4,988)

$830 (± $3,214)

$366 (± $2,026)

$332 (± $1,930)

$1,313 (± $4,913)

$ [$0 - $37,355]

$ [$0 - $12,449]

$ [$0 - $12,585]

$ [$0 - $12,585]

$ [$0 - $37,355]

 Emergency Room Visit Cost**

$44 (± $132)

$9 (± $36)

$6 (± $24)

$6 (± $23)

$42 (± $129)

$0 [$0 - $753]

$0 [$0 - $141]

$0 [$0 - $128]

$0 [$0 - $128]

$0 [$0 - $753]

 Outpatient Cost**

$767 (± $1,903)

$955 (± $1,538)

$1,048 (± $3,716)

$941 (± $3,545)

$802 (± $1,892)

$159 [$0 - $12,380]

$220 [$0 - $5,733]

$215 [$0 - $23,383]

$186 [$0 - $23,383]

$176 [$0 - $12,380]

 Osteoporosis Medication Cost** † ‡

$2,068 (± $1,196)

$7,420 (± $1,169)

$10,810 (± $1,250)

$10,516 (± $1,520)

$2,391 (± $1,746)

$1,713 [$779 - $5,259]

$7,350 [$5,744 - $9,631]

$10,969 [$8,811 - $14,910]

$10,748 [$6,836 - $14,910]

$1,735 [$779 - $9,631]

 Pain Medication Pharmacy Cost**

$216 (± $646)

$77 (± $172)

$440 (± $1,201)

$404 (± $1,150)

$208 (± $628)

$28 [$0 - $6,071]

$11 [$0 - $662]

$18 [$0 - $6,276]

$14 [$0 - $6,276]

$27 [$0 - $6,071]

  1. * Proportion of days covered.
  2. **Mean, standard deviation, median, [range].
  3. † ANOVA pairwise comparison between PDC < 50% and PDC ≥ 80% groups, p < 0.05.
  4. ‡ t-test between ‘Persistent’ and ‘Non-Persistent’ (60 Day Gap) groups, p < 0.05.