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Table 1 Gene ontology analysis of differentially expressed genes

From: Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes

Gene ontology term GO category Efron-Tibshirani’s GSA test p-value
Collagen/extracellular matrix association   
Collagen binding GO:0005518 < 0.005
Collagen metabolic process GO:0032963 0.05
Collagen catabolic process GO:0030574 0.035
Integrin complex GO:0008305 < 0.005
Substrate-bound cell migration GO:0006929 < 0.005
Negative regulation of cytoskeleton organization GO:0051494 0.025
Nitric oxide/monooxygenase activity   
Regulation of monooxygenase activity GO:0032768 < 0.005
Regulation of oxidoreductase activity GO:0051341 < 0.005
Regulation of nitric-oxide synthase activity GO:0050999 0.005
Nitric oxide biosynthetic process GO:0006809 0.015
Positive regulation of monooxygenase activity GO:0032770 0.005
Nitric oxide metabolic process GO:0046209 0.01
Regulation of nitric oxide biosynthetic process GO:0045428 0.005
Regulation of calcidiol 1-monooxygenase activity GO:0060558 0.005
Immune associated functions   
B cell receptor signaling pathway GO:0050853 0.015
Regulation of leukocyte mediated immunity GO:0002703 0.02
Response to interferon-gamma GO:0034341 0.005
Positive regulation of B cell activation GO:0050871 0.04
Humoral immune response mediated by circulating immunoglobulin GO:0002455 0.02
Myeloid cell activation during immune response GO:0002275 0.01
Regulation of lymphocyte mediated immunity GO:0002706 0.035
Muscle/myocyte/myofibroblast biology   
Dystroglycan binding GO:0002162 0.015
Myosin complex GO:0016459 0.01
Muscle filament sliding GO:0030049 0.02
Actin-myosin filament sliding GO:0033275 0.02
Myosin II complex GO:0016460 0.025
Actomyosin structure organization GO:0031032 0.04
Regulation of myoblast differentiation GO:0045661 0.03
Muscle myosin complex GO:0005859 0.02
Myoblast differentiation GO:0045445 0.02
Regulation of myotube differentiation GO:0010830 0.015
Myotube differentiation GO:0014902 0.005
  1. Gene ontology (GO) analysis was undertaken using BRB Array Tools. Significantly altered genesets were identified using Efron-Tibshirani’s Gene Set Analysis (GSA) test which tests which genesets contain more differentially expressed genes than would be expected by chance. The threshold of determining significant gene sets was 0.005.