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Table 6 Most connected proteins identified from the ProteinProphet protein pairs network

From: Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning

Most connected proteins Description
interleukin 8 (IL-8) A chemotactic factor known to attract neutrophils, basophils, and T-cells and is involved in neutrophil activation. IL-8 is released from a number of cell types in response to an inflammatory stimulus [46].
Matrix metalloproteinase-3 (MMP-3) MMP-3 can degrade fibronectin, laminin, some gelatins, various collagens and cartilage proteoglycans [47, 48].
Apolipoprotein E (APOE) APOE mediates the binding, internalization, and catabolism of lipoprotein particles [49, 50].
Matrix gla protein (MGP) MGP interacts with the matrix of bone and cartilage and is thought to act as an inhibitor of bone formation [51, 52].
Hyaluronan and proteoglycan link protein 1 (HPLN1) HPLN1 stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix [53].