interleukin 8 (IL-8)
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A chemotactic factor known to attract neutrophils, basophils, and T-cells and is involved in neutrophil activation. IL-8 is released from a number of cell types in response to an inflammatory stimulus [46].
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Matrix metalloproteinase-3 (MMP-3)
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MMP-3 can degrade fibronectin, laminin, some gelatins, various collagens and cartilage proteoglycans [47, 48].
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Apolipoprotein E (APOE)
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APOE mediates the binding, internalization, and catabolism of lipoprotein particles [49, 50].
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Matrix gla protein (MGP)
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MGP interacts with the matrix of bone and cartilage and is thought to act as an inhibitor of bone formation [51, 52].
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Hyaluronan and proteoglycan link protein 1 (HPLN1)
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HPLN1 stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix [53].
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