Table 6 Most connected proteins identified from the ProteinProphet protein pairs network
Most connected proteins | Description |
|---|---|
interleukin 8 (IL-8) | A chemotactic factor known to attract neutrophils, basophils, and T-cells and is involved in neutrophil activation. IL-8 is released from a number of cell types in response to an inflammatory stimulus [46]. |
Matrix metalloproteinase-3 (MMP-3) | MMP-3 can degrade fibronectin, laminin, some gelatins, various collagens and cartilage proteoglycans [47, 48]. |
Apolipoprotein E (APOE) | APOE mediates the binding, internalization, and catabolism of lipoprotein particles [49, 50]. |
Matrix gla protein (MGP) | MGP interacts with the matrix of bone and cartilage and is thought to act as an inhibitor of bone formation [51, 52]. |
Hyaluronan and proteoglycan link protein 1 (HPLN1) | HPLN1 stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix [53]. |