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Table 5 The ten mammalian proteins found most frequently in rules for each of the three classes, not including the default control class, from the ProteinProphet and emPAI combined dataset

From: Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning

IL-1β

Carprofen

IL-1β and Carprofen

Triosephosphate isomerase (19.8)

PP

Apolipoprotein E (13.7)

PP

interleukin 8 (33.8)

emPAI

Albumin (10)

emPAI

interleukin 8 (10.8)

emPAI

interleukin 8 (31)

PP

Triosephosphate isomerase (9.3)

emPAI

interleukin 8 (9.9)

PP

Clusterin (5.8)

emPAI

Matrix metalloproteinase 3 (7.6)

PP

Matrix gla protein (9.3)

PP

Matrix metalloproteinase 3 (5.7)

PP

Thrombospondin 1 (6.2)

PP

Hyaluronan and proteoglycan link protein 1 (8.4)

PP

Thrombospondin-3 (2.4)

emPAI

Serum amyloid A protein (3.5)

emPAI

Fibromodulin (7.4)

emPAI

Matrix metalloproteinase 3 (2.2)

emPAI

Matrix metalloproteinase 3 (3.4)

emPAI

Transmembrane protein PVRIG (4.6)

PP

Ribonuclease 4 (1.9)

PP

Enolase B (3)

emPAI

Matrix gla protein (3.2)

emPAI

Ribonuclease 4 (1.7)

emPAI

Keratin (2.5)

emPAI

Hyaluronan and proteoglycan link protein 1 (2.3)

emPAI

Cartilage intermediate layer protein 1 (1)

emPAI

Enolase A (2.4)

emPAI

Clusterin (2)

emPAI

Lumican (1)

emPAI

  1. The percentage of rules each protein was used in is shown in brackets. Alongside the proteins the table reports whether the rules were using the protein with its ProteinProphet probability (PP) or emPAI score.