Risk factors for incident hyperuricemia during mid-adulthood in African American and White men and women enrolled in the ARIC cohort study

Mara A McAdams-DeMarco; Andrew Law; Janet W Maynard; Josef Coresh; Alan N Baer

doi:10.1186/1471-2474-14-347

Table 2 Predictors of incident hyperuricemia over 9 years in the ARIC cohort

From: Risk factors for incident hyperuricemia during mid-adulthood in African American and White men and women enrolled in the ARIC cohort study

	Model 1^aRR (95% CI)	Model 2^aRR (95% CI)	Model 3^bRR (95% CI)	Model 4^bRR (95% CI)
Risk factor
Male sex	1.73 (1.36, 2.21)	1.10 (0.85, 1.43)	1.02 (0.80, 1.31)	1.54 (1.21, 1.97)
African American race	1.79 (1.37, 2.33)	1.68 (1.29, 2.18)	1.50 (1.15, 1.94)	1.64 (1.26, 2.13)
<High school education	1.27 (0.99, 1.63)	1.29 (1.00, 1.65)	1.15 (0.89, 1.49)	1.23 (0.96, 1.58)
Hypertension	1.65 (1.3, 2.09)	1.47 (1.15, 1.87)	1.27 (0.99, 1.62)	1.44 (1.12, 1.84)
Coronary heart disease	1.57 (0.99, 2.50)	1.60 (1.00, 2.56)	1.48 (0.90, 2.43)	1.45 (0.89, 2.37)
Smoking status
Current smoker	1.27 (0.97, 1.67)	1.29 (0.98, 1.69)	1.26 (0.96, 1.66)	1.27 (0.96, 1.66)
Former smoker	0.84 (0.64, 1.11)	0.81 (0.62, 1.07)	0.78 (0.60, 1.03)	0.83 (0.63, 1.09)
Never smoker	Reference	Reference	Reference	Reference
Body mass index, kg/m ²
BMI ≥ 35	3.47 (2.33, 5.18)	2.07 (1.37, 3.14)	2.18 (1.44, 3.31)	3.25 (2.16, 4.9)
30 ≤ BMI < 35	2.37 (1.65, 3.41)	1.76 (1.22, 2.54)	1.90 (1.31, 2.75)	2.37 (1.64, 3.40)
25 ≤ BMI < 30	2.01 (1.46, 2.78)	1.64 (1.19, 2.26)	1.79 (1.30, 2.46)	2.04 (1.48, 2.81)
BMI < 25	Reference	Reference	Reference	Reference
eGFR, ml/min/1.73 m ²
<60	2.85 (1.62, 5.01)	1.97 (1.12, 3.47)	2.05 (1.24, 3.39)	2.86 (1.70, 4.82)
60-90	1.12 (0.89, 1.42)	0.95 (0.75, 1.20)	1.05 (0.84, 1.32)	1.18 (0.94, 1.48)
≥ 90	Reference	Reference	Reference	Reference
Triglyceride, mg/dL
Quartile 4: ≥ 157	2.00 (1.38, 2.89)	1.48 (1.03, 2.13)	1.44 (1.01, 2.04)	1.93 (1.35, 2.76)
Quartile 3: 110 -156	1.46 (1.01, 2.12)	1.20 (0.83, 1.73)	1.12 (0.79, 1.60)	1.41 (0.99, 2.02)
Quartile 2: 79 - 109	1.08 (0.73, 1.60)	0.96 (0.65, 1.41)	1.00 (0.68, 1.46)	1.12 (0.76, 1.65)
Quartile 1: ≤ 78	Reference	Reference	Reference	Reference
Serum Urate Level at Visit1, mg/dL		2.33 (1.94, 2.80)
Serum Urate Level at Visit2, mg/dL			1.92 (1.78, 2.07)
Change in serum urate level (Visit 2-Visit 1), mg/dL				1.60 (1.47, 1.74)

^aThe number of participants included in analysis was 8,342.
^bThe number of participants included in analysis was 8,211.
Note: Relative risks and 95% confidence intervals are reported. Each model includes all the risk factors with relative risks and 95% confidence intervals listed in the column. Hyperuricemia was defined as serum urate levels greater than 7.0 mg/dL.

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