Table 2 Predictors of incident hyperuricemia over 9 years in the ARIC cohort

Male sex

1.73 (1.36, 2.21)

1.10 (0.85, 1.43)

1.02 (0.80, 1.31)

1.54 (1.21, 1.97)

African American race

1.79 (1.37, 2.33)

1.68 (1.29, 2.18)

1.50 (1.15, 1.94)

1.64 (1.26, 2.13)

<High school education

1.27 (0.99, 1.63)

1.29 (1.00, 1.65)

1.15 (0.89, 1.49)

1.23 (0.96, 1.58)

Hypertension

1.65 (1.3, 2.09)

1.47 (1.15, 1.87)

1.27 (0.99, 1.62)

1.44 (1.12, 1.84)

Coronary heart disease

1.57 (0.99, 2.50)

1.60 (1.00, 2.56)

1.48 (0.90, 2.43)

1.45 (0.89, 2.37)

Smoking status

Current smoker

1.27 (0.97, 1.67)

1.29 (0.98, 1.69)

1.26 (0.96, 1.66)

1.27 (0.96, 1.66)

Former smoker

0.84 (0.64, 1.11)

0.81 (0.62, 1.07)

0.78 (0.60, 1.03)

0.83 (0.63, 1.09)

Never smoker

Reference

Reference

Reference

Reference

Body mass index, kg/m ²

BMI ≥  35

3.47 (2.33, 5.18)

2.07 (1.37, 3.14)

2.18 (1.44, 3.31)

3.25 (2.16, 4.9)

30 ≤  BMI < 35

2.37 (1.65, 3.41)

1.76 (1.22, 2.54)

1.90 (1.31, 2.75)

2.37 (1.64, 3.40)

25 ≤  BMI < 30

2.01 (1.46, 2.78)

1.64 (1.19, 2.26)

1.79 (1.30, 2.46)

2.04 (1.48, 2.81)

BMI < 25

Reference

Reference

Reference

Reference

eGFR, ml/min/1.73 m ²

<60

2.85 (1.62, 5.01)

1.97 (1.12, 3.47)

2.05 (1.24, 3.39)

2.86 (1.70, 4.82)

60-90

1.12 (0.89, 1.42)

0.95 (0.75, 1.20)

1.05 (0.84, 1.32)

1.18 (0.94, 1.48)

≥ 90

Reference

Reference

Reference

Reference

Triglyceride, mg/dL

Quartile 4: ≥ 157

2.00 (1.38, 2.89)

1.48 (1.03, 2.13)

1.44 (1.01, 2.04)

1.93 (1.35, 2.76)

Quartile 3: 110 -156

1.46 (1.01, 2.12)

1.20 (0.83, 1.73)

1.12 (0.79, 1.60)

1.41 (0.99, 2.02)

Quartile 2: 79 - 109

1.08 (0.73, 1.60)

0.96 (0.65, 1.41)

1.00 (0.68, 1.46)

1.12 (0.76, 1.65)

Quartile 1: ≤  78

Reference

Reference

Reference

Reference

Serum Urate Level at Visit1, mg/dL

2.33 (1.94, 2.80)

Serum Urate Level at Visit2, mg/dL

1.92 (1.78, 2.07)

Change in serum urate level (Visit 2-Visit 1), mg/dL

1.60 (1.47, 1.74)