Table 1 Baseline risk factors by incident hyperuricemia in the ARIC cohort

Male sex

37

49**

Age, years

53.8 (6)

54.3 (5)

African American race

18

33**

High school education or higher

83

73**

Pre-menopause ^a,b

35

37

Smoking status ^a

Current smoker

22

27

Former smoker

31

28

Never smoker

47

45

Diuretic use

12

19**

Hypertension

24

44**

Total cholesterol, mmol/L

6 (1)

6 (1)

HDL cholesterol ^a

< 1.03 mmol/L

20

26*

1.03 ≤  HDL ≤  1.55

48

50

> 1.55

32

24

Diabetes

8

11*

Coronary heart disease

3

6*

Congestive heart failure

2

5*

BMI, kg/m ^2a

BMI ≥  35

6

14**

30 ≤  BMI < 35

15

23

25 ≤  BMI < 30

39

45

BMI < 25

40

18

Early adult obesity

3

7**

Weight change from early adult, lb

25 (26)

32 (30)**

Waist-to-hip ratio, quartiles ^a

Waist-to-hip ratio ≥  0.97

23

38**

0.92 ≤  Waist-to-hip ratio < 0.97

25

28

0.86 ≤ Waist -to-hip ratio < 0.92

26

22

0.86 ≤  Waist-to-hip ratio

26

12

Categorical alcohol intake, grams/week ^a

Abstain

61

63*

0–100

27

24

>100

12

13

Animal fat, grams/day

35 (17)

37 (18)*

Animal protein, grams/day

53 (23)

53 (22)

eGFR, ml/min/1.73 m ^2a

<60

1

4**

60–90

39

40

≥ 90

60

56

Baseline serum urate level, mg/dL

5.3 (1.0)

6.1 (0.78)**

Serum urate level at 3 year follow-up, mg/dL

5.5 (1.2)

7.0 (1.3)**

3-year change in serum urate level, mg/dL

0.2 (0.9)

0.9 (1.3)**