Skip to main content

Table 3 Distal femur BMD (mg/cm 2 ) in three rabbit Schenk assays

From: Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

Compound

Vehicle

Dose

ALN

  

1 mg/kg

3 mg/kg

10 mg/kg

30 mg/kg

 

L-833905

274.3 ± 4.5

–

–

282.5 ± 5.5

301.8 ± 4.9**

314.0 ± 9.1**

L-006235

263.3 ± 4.5

281.7 ± 4.9**

293.5 ± 2.8***

303.5 ± 5.4***

–

300.5 ± 4.6***

L-873724

285.5 ± 5.4

301.2 ± 3.7

310.5 ± 6.5**

327.7 ± 7.5***

–

352.8 ± 9.4***

  1. Mean ± standard error of the mean; **p < 0.01, ***p < 0.001 vs. vehicle.
  2. ALN = alendronate, BMD = bone mineral density.
Back to article page

BMC Musculoskeletal Disorders

ISSN: 1471-2474

Contact us