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Table 3 Distal femur BMD (mg/cm 2 ) in three rabbit Schenk assays

From: Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

Compound Vehicle Dose ALN
   1 mg/kg 3 mg/kg 10 mg/kg 30 mg/kg  
L-833905 274.3 ± 4.5 282.5 ± 5.5 301.8 ± 4.9** 314.0 ± 9.1**
L-006235 263.3 ± 4.5 281.7 ± 4.9** 293.5 ± 2.8*** 303.5 ± 5.4*** 300.5 ± 4.6***
L-873724 285.5 ± 5.4 301.2 ± 3.7 310.5 ± 6.5** 327.7 ± 7.5*** 352.8 ± 9.4***
  1. Mean ± standard error of the mean; **p < 0.01, ***p < 0.001 vs. vehicle.
  2. ALN = alendronate, BMD = bone mineral density.