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Table 1 Effect of 10 days' ALN treatment on DFBMD in growing rabbits

From: Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

ALN dose (μg/kg)

DFBMD (mg/cm2)

% BMD gain

 

Veh

ALN

 

50

241.4 ± 9.2

277.8 ± 8.4**

15

100

270.5 ± 7.9

313.7 ± 3.9***

16

200

242.0 ± 3.4

281.7 ± 6.4***

16

500

241.6 ± 5.2

291.2 ± 9.4***

21

  1. Mean ± standard error of the mean; **p < 0.01, ***p < 0.001 vs. vehicle.
  2. ALN = alendronate, DFBMD = distal femoral bone mineral density, Veh = vehicle.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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