Efficacy of low-dose intra-articular tranexamic acid in total knee replacement; a prospective triple-blinded randomized controlled trial

Table 4 Comparison of the previous RCT studies using tranexamic acid (TXA) as a single intra-articular agent with this study

Studies	TXA dosage (g)	Bone cutting guide	Prosthesis	Technique used	DBL		THL	CTBL	BT
					Early❖	Total
Wong (2010) [12]	1.5 & 3.0	IM	Triathlon, Genesis II	5 min T.A., no drain	n/a	n/a	Sig	Sig	NS
Maniar (2012) [7]	3.0	EM	PFC Σ	5 min T.A., clamp drain♯ 2 hr then fully open	Sig	NS	n/a	Sig	NS
Ishida (2011) [6]	2.0	IM	Advance, Nexgen, Scorpio, Vanguard, PFC Σ	IA, clamp drain 30 min then gradually open	Sig	NS	Sig	Sig	NS
Seo (2012) [11]	1.5	EM	Scorpio	IA, with non-clamp drain	n/a	Sig	Sig	n/a	Sig
Roy (2012) [10]	0.5	IM	Scorpio	IA, clamp drain 1 hr then fully open	Sig	Sig	Sig	n/a	Sig
Sa-ngasoongsong (2011) [9]	0.25	EM	LCS, PFC Σ	IA, clamp drain 2 hr then fully open	Sig	Sig	Sig	Sig	Sig
This study	0.25, 0.5	IM	Nexgen	IA, clamp drain 2 hr then fully open	Sig.	N-S	Sig.	Sig.	Sig

TXA; Tranexamic Acid, DBL; drainage blood loss, ❖; accumulated DBL in early period (6-24 hours after surgery).
THL; total hemoglobin loss, CTBL; calculated total blood loss, BT; blood transfusion.
IM; intramedullary femoral cutting guide, EM; extramedullary femoral cutting guide.
T.A; Topical application, IA; intra-articlar, min; minute, hr; hour, ♯; intra-articular drain.
n/a; not available, Sig; significant reduction compared with control group, NS; non-significant difference compared with control group.

ISSN: 1471-2474