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Table 2 Comparative studies on PRP clinical application to favor bone-graft, bone-graft substitutes, or bone implant integration

From: Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review

 

Publication

Results

 

Publication

Results

Autologous bone

Luaces-Rey R [18] Med Oral Patol Oral Cir Bucal - 2010

Bone increase between the third and sixth months, in autologous bone alone or in combination with PRP without any statistical difference

BPBM

Camargo PM [13] Int J Per Rest Dent - 2005

Decrease in pocket depth and an increase in clinical attachment level and defect filling, with BPBM, GTR, and PRP in comparison to open flap debridement group

Bettega G [22] Transfusion - 2009

PRP permitted a 60% reduction in the amount of bone graft required for normal sinus floor augmentation and the bone obtained had the same histological and mechanical properties as the bone obtained by traditional graft

Lekovic V [17] J Clin Periodontol - 2003

Greater pocket reduction, an increase in clinical attachment level, vertical and horizontal defect filling in the BPBM/GTR/PRP group respect to open flap debridement

Lee C [24] Int J Oral Maxillofac Surg - 2009

PRP acceleration of early bone remodelling, but no significant differences in bone resorption rate between PRP and particulate cancellous bone and marrow (PCBM) vs PCBM alone

Camargo PM [19] J Periodontal Res - 2002

High pocket depth reduction, clinical attachment gain and defect filling in the PRP/BPBM group

BPBM

Anitua E [38] Clin Impl Dent Rel Res - 2012

More new vital bone than that of the controls in PRGF-treated samples, and well incorporated bovine into the new bone formation in the PRGF group

β-TCP

Saini N [23] Indian J Dent Res - 2011

Clinical and radiographic improvement when PRP was added to β-TCP

Cabbar F [40] J Oral Maxillofac Surg - 2011

No significant differences in BPBM plus PRP or alone: bone integration and residual graft particles in all patients at histological analysis

Ti

Monov G [52] Clin Oral Implants Res - 2005

No statistically significant differences between titanium plus PRP or titanium alone group

Yilmaz S [42] J Periodontol - 2011

At 12 months, similar results in probing depth reduction, attachment gain, clinical and radiographic bone gain between BPBM plus PPP or plus PRP groups

Biomaterials combination

Poeschl PW [53] J Oral Maxillofac Surg - 2012

Significantly better overall graft resorption and increase in bone formation occurred when PRP was added to algae-derived HA, Cgraft and Algipore respect to biomaterials alone

Camargo PM [44] J Periodontol - 2009

Similar results between BPBM/GTR alone or in combination with PRP in the decrease of probing depth, gain in clinical attachment and bone filling of the defect.

Inchingolo F [54] Eur Rev Med Pharmacol Sci - 2012

At radiographic point of view presence of newly formed bone tissue, well amalgamated with the residual bone in PRP plus autologous bone, anorganic bone material (Bio-Oss, HA) and organic bone substitutes vs autologous bone alone