Figure 5
From: Knee loading reduces MMP13 activity in the mouse cartilage
Effects of knee loading (1 N) to OA mice on the activity levels of collagenases, gelatinases, and MMP13, as well as the phosphorylation levels of p38 MAPK and NFκB. (A) Collagenase activity in the control, OA, and loaded OA cartilages. (B) Gelatinase activity in the control, OA, and loaded OA cartilages. (C) MMP13 activity in the control, OA, and loaded OA cartilages. (D) Levels of p-p38 in the control, OA, and loaded OA cartilages (60 min after knee loading). n = 3 per group (A-D). (E) Levels of p-NFκB in the control, OA, and loaded OA cartilages (15, 30, and 60 min after knee loading). n = 3 per control, OA, and OA + loaded (15, 30, and 60 min), respectively.