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Table 2 Summary of the meta-analysis findings of the association between HLA-DRB1 alleles and RA

From: Meta-analysis of the association of HLA-DRB1 with rheumatoid arthritis in Chinese populations

Polymorphisms Eligible studies RA Case n/N Control n/N OR (95% CI) p–value Heterogeneity test Effect model
HLA–DRB1*04 12 489/965 240/1166 4.19 (3.44 – 5.11) <0.00001 p=0.93, I [2]=0% Fixed
  Northerner 5 248/528 111/566 3.67 (2.78 – 4.84) <0.00001 p=0.96, I [2]=0%  
  Southerner 7 241/437 129/600 4.83 (3.64 – 6.4) <0.00001 p=0.86, I [2]=0%  
HLA–DRB1*0401 10 54/733 24/814 2.53 (1.54 – 4.16) 0.0003 p=0.91, I [2]=0% Fixed
  Northerner 5 31/397 16/390 2 (1.06 – 3.79) 0.003 p=0.87, I [2]=0%  
  Southerner 5 23/336 8/424 3.59 (1.6 – 8.06) 0.002 p=0.78, I [2]=0%  
HLA–DRB1*0402 1 4/287 2/196 1.41 (0.31 – 6.42) 0.65 p=0.75, I [2]=0% Fixed
HLA–DRB1*0404 10 44/733 19/814 2.28 (1.28 – 4.06) 0.005 p=0.91, I [2]=0% Fixed
  Northerner 5 31/397 10/390 2.46 (1.14 – 5.28) 0.02 p=0.75, I [2]=0%  
  Southerner 5 13/336 9/424 2.06 (0.85 – 4.94) 0.11 p=0.72, I [2]=0%  
HLA–DRB1*0405 11 240/913 91/914 3.71 (2.52 – 5.45) <0.00001 p=0.10, I [2]=38% Random
  Northerner 6 142/577 54/490 3.17 (1.84 – 5.48) <0.00001 p=0.11, I [2]=44%  
  Southerner 5 98/336 37/424 4.56 (2.69 – 7.73) <0.00001 p=0.26, I [2]=25%  
HLA–DRB1*0408 9 16/620 7/757 2.24 (0.94 – 5.34) 0.07 p=0.77, I [2]=0% Fixed
  Northerner 5 13/295 5/350 2.27 (0.82 – 6.29) 0.12 p=0.51, I [2]=0%  
  Southerner 4 3/325 2/407 2.18 (0.42 – 11.3) 0.35 p=0.63, I [2]=0%  
HLA–DRB1*0409 8 8/578 3/743 2.78 (0.92 – 8.42) 0.07 p=0.43, I [2]=0% Fixed
  Northerner 4 6/253 2/336 3.28 (0.85 – 12.57) 0.08 p=0.22, I [2]=35%  
  Southerner 4 2/325 1/407 1.91 (0.26 – 13.95) 0.53 p=0.93, I [2]=0%  
HLA–DRB1*0410 8 15/578 7/743 2.99 (1.25 – 7.14) 0.01 p=0.93, I [2]=0% Fixed
  Northerner 4 4/253 1/336 3.96 (0.71 – 22.12) 0.12 p=0.92, I [2]=0%  
  Southerner 4 11/325 6/407 2.7 (0.98 – 7.42) 0.05 p=0.58, I [2]=0%  
HLA–DRB1*01 8 45/557 45/785 1.35 (0.87 – 2.11) 0.18 p=0.87, I [2]=0% Fixed
  Northerner 4 25/292 27/436 1.45 (0.8 – 2.61) 0.22 p=0.63, I [2]=0%  
  Southerner 4 20/265 18/349 1.23 (0.62 – 2.45) 0.55 p=0.72, I [2]=0%  
HLA–DRB1*0101 1 9/245 9/356 1.48 (0.57 – 3.84) 0.42 p=0.92, I [2]=0% Fixed
HLA–DRB1*0102 1 4/245 5/356 1.08 (0.3 – 3.9) 0.9 p=0.95, I [2]=0% Fixed
HLA–DRB1*10 5 20/417 18/538 1.3 (0.67 – 2.52) 0.43 p=0.69, I [2]=0% Fixed
  Northerner 3 16/253 14/336 1.34 (0.64 – 2.84) 0.44 p=0.44, I [2]=0%  
  Southerner 2 4/164 4/202 1.17 (0.29 – 4.71) 0.82 p=0.43, I [2]=0%  
  1. 'n’ stands for number of positive events, 'N’ stands for number of total events.