Table 2 Summary of the meta-analysis findings of the association between HLA-DRB1 alleles and RA
From: Meta-analysis of the association of HLA-DRB1 with rheumatoid arthritis in Chinese populations
| Polymorphisms | Eligible studies | RA Case n/N | Control n/N | OR (95% CI) | p–value | Heterogeneity test | Effect model |
|---|---|---|---|---|---|---|---|
| HLA–DRB1*04 | 12 | 489/965 | 240/1166 | 4.19 (3.44 – 5.11) | <0.00001 | p=0.93, I [2]=0% | Fixed |
| Northerner | 5 | 248/528 | 111/566 | 3.67 (2.78 – 4.84) | <0.00001 | p=0.96, I [2]=0% | |
| Southerner | 7 | 241/437 | 129/600 | 4.83 (3.64 – 6.4) | <0.00001 | p=0.86, I [2]=0% | |
| HLA–DRB1*0401 | 10 | 54/733 | 24/814 | 2.53 (1.54 – 4.16) | 0.0003 | p=0.91, I [2]=0% | Fixed |
| Northerner | 5 | 31/397 | 16/390 | 2 (1.06 – 3.79) | 0.003 | p=0.87, I [2]=0% | |
| Southerner | 5 | 23/336 | 8/424 | 3.59 (1.6 – 8.06) | 0.002 | p=0.78, I [2]=0% | |
| HLA–DRB1*0402 | 1 | 4/287 | 2/196 | 1.41 (0.31 – 6.42) | 0.65 | p=0.75, I [2]=0% | Fixed |
| HLA–DRB1*0404 | 10 | 44/733 | 19/814 | 2.28 (1.28 – 4.06) | 0.005 | p=0.91, I [2]=0% | Fixed |
| Northerner | 5 | 31/397 | 10/390 | 2.46 (1.14 – 5.28) | 0.02 | p=0.75, I [2]=0% | |
| Southerner | 5 | 13/336 | 9/424 | 2.06 (0.85 – 4.94) | 0.11 | p=0.72, I [2]=0% | |
| HLA–DRB1*0405 | 11 | 240/913 | 91/914 | 3.71 (2.52 – 5.45) | <0.00001 | p=0.10, I [2]=38% | Random |
| Northerner | 6 | 142/577 | 54/490 | 3.17 (1.84 – 5.48) | <0.00001 | p=0.11, I [2]=44% | |
| Southerner | 5 | 98/336 | 37/424 | 4.56 (2.69 – 7.73) | <0.00001 | p=0.26, I [2]=25% | |
| HLA–DRB1*0408 | 9 | 16/620 | 7/757 | 2.24 (0.94 – 5.34) | 0.07 | p=0.77, I [2]=0% | Fixed |
| Northerner | 5 | 13/295 | 5/350 | 2.27 (0.82 – 6.29) | 0.12 | p=0.51, I [2]=0% | |
| Southerner | 4 | 3/325 | 2/407 | 2.18 (0.42 – 11.3) | 0.35 | p=0.63, I [2]=0% | |
| HLA–DRB1*0409 | 8 | 8/578 | 3/743 | 2.78 (0.92 – 8.42) | 0.07 | p=0.43, I [2]=0% | Fixed |
| Northerner | 4 | 6/253 | 2/336 | 3.28 (0.85 – 12.57) | 0.08 | p=0.22, I [2]=35% | |
| Southerner | 4 | 2/325 | 1/407 | 1.91 (0.26 – 13.95) | 0.53 | p=0.93, I [2]=0% | |
| HLA–DRB1*0410 | 8 | 15/578 | 7/743 | 2.99 (1.25 – 7.14) | 0.01 | p=0.93, I [2]=0% | Fixed |
| Northerner | 4 | 4/253 | 1/336 | 3.96 (0.71 – 22.12) | 0.12 | p=0.92, I [2]=0% | |
| Southerner | 4 | 11/325 | 6/407 | 2.7 (0.98 – 7.42) | 0.05 | p=0.58, I [2]=0% | |
| HLA–DRB1*01 | 8 | 45/557 | 45/785 | 1.35 (0.87 – 2.11) | 0.18 | p=0.87, I [2]=0% | Fixed |
| Northerner | 4 | 25/292 | 27/436 | 1.45 (0.8 – 2.61) | 0.22 | p=0.63, I [2]=0% | |
| Southerner | 4 | 20/265 | 18/349 | 1.23 (0.62 – 2.45) | 0.55 | p=0.72, I [2]=0% | |
| HLA–DRB1*0101 | 1 | 9/245 | 9/356 | 1.48 (0.57 – 3.84) | 0.42 | p=0.92, I [2]=0% | Fixed |
| HLA–DRB1*0102 | 1 | 4/245 | 5/356 | 1.08 (0.3 – 3.9) | 0.9 | p=0.95, I [2]=0% | Fixed |
| HLA–DRB1*10 | 5 | 20/417 | 18/538 | 1.3 (0.67 – 2.52) | 0.43 | p=0.69, I [2]=0% | Fixed |
| Northerner | 3 | 16/253 | 14/336 | 1.34 (0.64 – 2.84) | 0.44 | p=0.44, I [2]=0% | |
| Southerner | 2 | 4/164 | 4/202 | 1.17 (0.29 – 4.71) | 0.82 | p=0.43, I [2]=0% |