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Table 3 Summary of safety and tolerability

From: Evaluation of etoricoxib in patients undergoing total knee replacement surgery in a double-blind, randomized controlled trial

  Placebo Etoricoxib Etoricoxibn Ibuprofen
N = 98 90 mg  120 mg 1800 mg 
n(%) N = 222 N = 230 N = 223
  n(%) n(%) n(%)
One or more AEs 68 (69.4) 141 (63.5) 144 (62.6) 134 (60.1)
   Discontinued due to AEs 5 (5.1) 14 (6.3) 8 (3.5) 10 (4.5)
Drug-related AEs 3 (3.1) 12 (5.4) 11 (4.8) 9 (4.0)
   Discontinued due to Drug-related AEs 1 (1.0) 2 (0.9) 1 (0.4) 3 (1.3)
Serious AEs 4 (4.1) 5 (2.3) 4 (1.7) 5 (2.2)
Discontinued due to Serious AEs 1 (1.0) 4 (1.8) 2 (0.9) 2 (0.9)
Tier 1 AEs
  CHF, pulmonary edema, or cardiac failure composite 0 (0.0) 1 (0.5) 0 (0.0) 0 (0.0)
  Edema-related 4 (4.1) 2 (0.9) 4 (1.7) 4 (1.8)
  Hypertension-related 3 (3.1) 8 (3.6) 3 (1.3) 7 (3.1)
  Opioid-related 41 (41.8) 77 (34.7) 84 (36.5) 81 (36.3)
Tier 2 AEs (AEs that occurred in ≥4 patients in any one treatment group)
  Constipation 13 (13.3) 26 (11.7) 33 (14.3) 30 (13.5)
  Dyspepsia 8 (8.2) 5 (2.3) 9 (3.9) 10 (4.5)
  Nausea 31 (31.6) 50 (22.5) 56 (24.3) 53 (23.8)
  Vomiting 13 (13.3) 27 (12.2) 30 (13.0) 33 (14.8)
  Edema peripheral 4 (4.1) 2 (0.9) 4 (1.7) 4 (1.8)
  Pyrexia 27 (27.6) 13 (5.9) 25 (10.9) 23 (10.3)
  Anaemia (postoperative) 4 (4.1) 11 (5.0) 6 (2.6) 6 (2.7)
  Dizziness 3 (3.1) 14 (6.3) 15 (6.5) 14 (6.3)
  Headache 3 (3.1) 9 (4.1) 7 (3.0) 6 (2.7)
  Insomnia 11 (11.2) 23 (10.4) 21 (9.1) 17 (7.6)
  Oliguria 4 (4.1) 2 (0.9) 6 (2.6) 4 (1.8)
  Hyperhidrosis 4 (4.1) 14 (6.3) 14 (6.1) 11 (4.9)
  Pruritus 4 (4.1) 19 (8.6) 15 (6.5) 17 (7.6)
AEs of Interest in Postoperative Patients
  Bleeding-related AEs 7 (7.1) 16 (7.2) 11 (4.8) 14 (6.3)
  Wound infection-related AEs 0 (0.0) 4 (1.8) 1 (0.4) 5 (2.2)
  Wound-related AEs 2 (2.0) 1 (0.5) 2 (0.9) 2 (0.9)
All Confirmed Thromboembolic Events
  Myocardial Infarction 0 (0.0) 1 (0.5) 1 (0.4) 0 (0.0)
  Transient Ischemic Attack 1 (1.0) 0 (0.0) 0 (0.0) 0 (0.0)
  Pulmonary Embolism 0 (0.0) 1 (0.5) 1 (0.4) 0 (0.0)
  Cardiac Arrest 1 (1.0) 0 (0.0) 0 (0.0) 0 (0.0)