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Table 1 Classification and prognosis of different types of autosomal recessive proximal spinal muscular atrophy[1, 2]

From: Natural course of scoliosis in proximal spinal muscular atrophy type II and IIIa: descriptive clinical study with retrospective data collection of 126 patients

Types Manifestation Functional grading Life expectancy
Ia more severe prenatal (30%) to 3-6 months unable to roll over or sit < 30 months = 100%
< 18 months = 95%
< 7 months = 50%
Ib less severe like Ia like Ia 2.5 - 20 years *
II intermediate birth -18 months sitting 2.5 - 30 years *
IIIa mild, retarded motor development to 3 years walking 4th – 6th decade, usually normal
IIIb mild, normal motor development > 3 - 30 years walking
IV adult > 30 years walking normal
  1. * Longer life expectancy is quite possible.