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Figure 8 | BMC Musculoskeletal Disorders

Figure 8

From: Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition

Figure 8

Treated defects elicit osteoclast chemotaxis to the bone plate and subchondral bone remodeling. Representative TRAP-stained decalcified sagittal sections at 1.25x (A, D, G) and 40x magnifications (B, E, H). (A, B) No osteoclasts were present in day 1 defects. (D, E) In treated defects after 21 days, numerous osteoclasts have migrated to the subchondral bone plate. (G, H). In control defects after 21 days, many osteoclasts have formed deeper in the repairing bone defect, but not at the subchondral bone plate level. (C, F, I) 2D-micro-CT images of mineralized tissue in matching sagittal sections show strong subchondral bone remodeling in treated defects, in contrast with the control defects with negligible remodeling of the hole sidewalls. Symbols: AC, Cartilage; B, Bone; I, Implant; RI, Residual implant; RT, Repair tissue.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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