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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition

Figure 2

Chitosan-NaCl/blood implants reside in osteochondral drill holes for 21 days post-operative. (A) Microdrilled defects in rabbit trochlea. (B) Microdrilled defects in rabbit trochlea after press-fitting 3 pre-solidified implants (arrows). (C) Control defects after 1 day show a blood clot inside the holes (the distal control defect was treated with Tissue Factor). (D) Treated defects after 1 day show implants inside the holes. (E) Control defects after 3 weeks are filled with a white fibrous or fibrocartilage repair tissue. (F) Treated defects after 3 weeks are filled with a mixture of red angiogenic granulation tissue and white granulation tissue containing neutrophils or stromal cells. (G, H) 1.25x magnification epifluorescence pictures with 200ms exposure of whole knee trochlea shows three defects that retained RITC-chitosan after (G) 1 day and (H) 21 days.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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