Figure 10From: Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition Bone resorption and repair in chitosan-treated defects (A- C) versus minor endochondral bone repair in controls (D-F). Gomori Trichrome-stained sagittal cryosections of (A, B) a 10K-treated defect and (D, E) a distal control defect and matching Safranin O-fast green-stained section (C, 10K-treated defect; F, control defect). Symbols: Vertical bar: initial defect 2 mm depth; black arrows: zone of previous bone resorption (thick arrow) and woven bone repair (thin arrow); black arrowhead: blood vessels; white arrowhead: new woven bone; star: bone-induced chondroinduction [12, 22].Back to article page