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Table 10 Genotype frequencies of four polymorphisms in ONFH patients in the relation to number of affected joints (total, unilateral and bilateral ONFH) and controls

From: Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland

Genotype

Controls N=100

Patients

Total N=68

Unilateral n=29

Bilateral n=39

Factor V Leiden

GA

3(3%)

3(4,41%)

2(6,89%)

1(2,56%)

GG

97(97%)

65(95,59%)

27(93,11%)

38(97,44%)

Prothrombin

GA

2(2%)

1(1,47%)

1(3,44%)

0

GG

98(98%)

67(98,53%)

28(96,56%)

39(100%)

MTHFR

TT

7(7%)

4(5,88%)

2(6,89%)

2(5,12%)

CT

42(42%)

35(51,47%)

14(48,27%)

21(53,84%)

CC

51(51%)

29(42,65%)

13(44,84%)

16(41,04%)

TPA

DD

18(18%)

13(19,12%)

3(10,34%)

10(25,64%)a

ID

37(37%)

38(55,88%)b

17(58,62%)

21(53,84%)c

II

45(45%)

17(25%)

9(31,04%)

8(20,52%)

  1. ap=0,034; odds ratio (OR) 3,12; 95% confidence intervals (CIs) 1,06-9,18.
  2. bp=0,004; OR 2,71; 95% CIs 1,32-5,57.
  3. cp=0,009; OR 3,19; 95% CIs 1,26-8,03.