Visit | Total study population (N = 1561) | Group A | Group B | Group C | Group D | |||||
---|---|---|---|---|---|---|---|---|---|---|
Recent prior fracturea; incident fracture (N = 119) | Recent prior fracturea; no incident fracture (N = 646) | No recent prior fracturea; incident fracture (N = 89) | No recent prior fracturea; no incident fracture (N = 727) | |||||||
n | Â | n | Â | n | Â | n | Â | n | Â | |
EQ-VAS, mean (SD) | ||||||||||
Baseline | 1558 | 52.01(22.0) | 117 | 48.4 (22.0) | 636 | 51.4 (21.8) | 88 | 49.3 (21.6) | 717 | 53.5 (22.1) |
3 months | 1434 | 59.0 (19.8) | 105 | 54.9 (18.9) | 584 | 59.3 (19.6) | 81 | 55.2 (17.4) | 664 | 59.8 (20.4) |
6 months | 1401 | 61.94(20.1) | 110 | 56.1 (17.8)*†| 579 | 63.3 (19.0) | 85 | 53.6 (19.8)‡ | 627 | 62.9 (21.0) |
12 months | 1304 | 64.5 (21.4) | 106 | 56.5 (20.7)**††| 528 | 65.5 (20.5) | 84 | 57.9 (17.9)‡ | 586 | 66.0 (22.4) |
18 months | 1249 | 67.5 (21.4) | 101 | 60.6 (20.9)**††| 514 | 68.8 (20.5) | 79 | 57.8 (18.8)‡‡ | 555 | 68.9 (22.1) |
24 months | 1068 | 67.4 (22.4) | 91 | 58.9 (24.1)**†| 416 | 69.6 (20.9) | 71 | 54.8 (21.0)‡‡ | 490 | 68.9 (22.6) |
36 months | 951 | 68.7 (22.5) | 79 | 60.1 (23.7)*†| 385 | 70.2 (21.6) | 65 | 57.9 (22.4)‡‡ | 422 | 70.7 (22.3) |
Endpointb | 1513 | 64.6 (23.1) | 116 | 57.1 (24.3)*†| 615 | 65.5 (22.5) | 84 | 55.7 (22.5)‡‡ | 698 | 66.2 (23.2) |
EQ-5D index score, median (Q1, Q3) | ||||||||||
Baseline | 1535 | 0.59 (0.08,0.73) | 116 | 0.23 (−0.02, 0.67)††| 623 | 0.59 (0.03, 0.73) | 86 | 0.57 (0.17, 0.69) | 710 | 0.59 (0.09, 0.73) |
3 months | 1409 | 0.69 (0.52, 0.76) | 103 | 0.62 (0.29, 0.73)*†| 577 | 0.69 (0.52, 0.76) | 80 | 0.62 (0.23, 0.74) | 649 | 0.69 (0.52, 0.80) |
6 months | 1367 | 0.69 (0.52, 0.80) | 108 | 0.62 (0.52, 0.71)**††| 564 | 0.69 (0.59, 0.80) | 83 | 0.62 (0.26, 0.73)‡‡ | 612 | 0.69 (0.59, 0.80) |
12 months | 1289 | 0.69 (0.59, 0.80) | 106 | 0.69 (0.52, 0.76)*††| 522 | 0.69 (0.59, 0.80) | 85 | 0.62 (0.26, 0.73)‡‡ | 576 | 0.73 (0.59, 0.85) |
18 months | 1233 | 0.73 (0.59, 0.85) | 102 | 0.66 (0.52, 0.74)**††| 513 | 0.73 (0.62, 0.85) | 80 | 0.62 (0.52, 0.76)‡‡ | 538 | 0.73 (0.59, 0.85) |
24 months | 1057 | 0.73 (0.59, 0.85) | 87 | 0.62 (0.09, 0.73)**††| 410 | 0.73 (0.62, 0.88) | 73 | 0.69 (0.31, 0.80)‡ | 487 | 0.73 (0.59, 0.88) |
36 months | 939 | 0.73 (0.59, 0.88) | 75 | 0.62 (0.15, 0.76)**††| 377 | 0.76 (0.62, 1.00) | 66 | 0.69 (0.52, 0.80)‡ | 421 | 0.76 (0.62, 1.00) |
Endpointb | 1483 | 0.69 (0.52, 0.80) | 111 | 0.59 (0.09, 0.76)**††| 605 | 0.69 (0.59, 0.80) | 85 | 0.69 (0.36, 0.76)‡ | 682 | 0.73 (0.52, 0.85) |