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Table 4 Changes in secondary efficacy variables

From: Efficacy and safety of diclofenac diethylamine 1.16% gel in acute neck pain: a randomized, double-blind, placebo-controlled study

  Time after first application of study drug
24 hours 48 hours 96 hours
Efficacy variable DDEA 1.16% gel Placebo DDEA 1.16% gel Placebo DDEA 1.16% gel Placebo
Pain-at-rest – mean ± SD, mm (% difference from baseline) 18.5 ± 11.3* (55.0) 36.3 ± 16.0 (9.5) 6.5 ± 7.6* (84.2) 29.2 ± 15.7 (27.2) 1.2 ± 2.9* (97.1) 19.2 ± 11.9 (52.1)
Neck disability index score – mean ± SD (% difference from baseline) 16.0 ± 7.1* (36.8) 21.9 ± 7.9 (7.2) 7.8 ± 2.9* (69.2) 19.9 ± 8.4 (15.7) 2.8 ± 3.0* (88.9) 14.6 ± 6.8 (38.1)
  1. * ANCOVA (analysis-of-covariance test with treatment and site as main effects and the baseline pain-at-rest value as a covariate): p < 0.0001 versus placebo. SD = standard deviation.