Median value for serum-COMP over the first 2 years in the groups. (A) shows the median value for serum-COMP over the first 2 years in the groups. The inserts show the individual changes between inclusion and the 3 month follow up in the group with unchanged serum-COMP levels (UnCh, N=142) (B), the group with decreasing levels (DeCr, N=173) (C) and the group with increasing levels (InCr, N=34) (D). The median values in the inserts are shown as a horisontal line. For further explanation, see text.