CTX-II, plasma levels. On day 1, 2 mg MIA in 25 μl saline were delivered in the left knee articular cavity. Collagen was suspended in 1% CMC and p.o. daily administered starting on day 1. Control animals were treated with vehicle. On day 14 plasma samples were collected and analyzed by ELISA kit. Each value represents the mean of 12 rats performed in 2 different experimental set. *P < 0.01 compared to vehicle + vehicle rats; §P < 0.05 and ^P < 0.01 compared to MIA + vehicle treated rats.