Hind limb weight bearing alterations, Incapacitance test. The effect of collagen (daily administered starting on day 1) on MIA-induced articular damage was evaluated on day 14. Data are expressed as the difference between the weight applied on the limb contralateral to the injury and the weight applied on the ipsilateral one. Control animals were treated with vehicle. Each value represents the mean of 12 rats performed in 2 different experimental set. *P < 0.01 vs vehicle + vehicle rats; §P < 0.05 and ^P < 0.01 vs MIA + vehicle treated rats.