Figure 2From: Low dose native type II collagen prevents pain in a rat osteoarthritis model Pain: non-noxious stimuli. Von Frey test was used to measure the response evoked by a mechanical stimulus 14 days after MIA injection. 1, 3 or 10 mg kg-1 collagen were p.o. administered every day starting on the 1th day suddenly after MIA. Control animals were treated with vehicle. Each value represents the mean of 12 rats performed in 2 different experimental set.*P < 0.01 vs contralateral paw; §P < 0.05 and ^P < 0.01 vs MIA + vehicle treated rats.Back to article page