|
36 years
|
43 years
|
53 years
|
---|
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
---|
Manual occupation
|
1.85 (1.06, 3.24)
|
0.031
|
1.09 (0.66, 1.82)
|
0.734
|
1.87 (1.22, 2.86)
|
0.004
|
Non-manual occupation
|
Referent
| |
Referent
| |
Referent
| |
BMI (per z-score)
|
1.49 (1.16, 1.91)
|
0.002
|
1.73 (1.39, 2.15)
|
<0.001
|
1.92 (1.59, 2.33)
|
<0.001
|
p-value for test of interaction
| |
0.691
| |
0.570
| |
0.203
|
Lifting unlikely
|
0.89 (0.51, 1.55)
|
0.681
|
1.10 (0.67, 1.81)
|
0.710
|
0.71 (0.42, 1.19)
|
0.317
|
Lifting somewhat likely
|
Referent
| |
Referent
| |
Referent
| |
Lifting highly likely
|
0.73 (0.32, 1.66)
|
0.449
|
1.09 (0.55, 2.18)
|
0.070
|
1.02 (0.51, 2.07)
|
0.590
|
BMI (per z-score)
|
1.80 (1.47, 2.21)
|
<0.001
|
1.85 (1.52, 2.25)
|
<0.001
|
1.73 (1.49, 2.24)
|
<0.001
|
p-value for test of interaction
| |
0.344
| |
0.580
| |
0.808
|
Kneeling unlikely
|
0.74 (0.49, 1.11)
|
0.143
|
0.79 (0.52, 1.18)
|
0.248
|
0.93 (0.58, 1.51)
|
0.776
|
Kneeling somewhat likely
|
Referent
| |
Referent
| |
Referent
| |
Kneeling highly likely
|
0.91 (0.45, 1.85)
|
0.793
|
0.80 (0.41, 1.59)
|
0.530
|
1.23 (0.58, 2.61)
|
0.582
|
BMI (per z-score)
|
1.78 (1.45, 2.18)
|
<0.001
|
1.83 (1.50, 2.22)
|
<0.001
|
1.91 (1.29, 2.83)
|
<0.001
|
p-value for test of interaction
| |
0.295
| |
0.780
| |
0.405
|
Sitting unlikely
|
1.15 (0.72, 1.84)
|
0.549
|
0.76 (0.47, 1.24)
|
0.276
|
1.29 (0.77, 2.16)
|
0.343
|
Sitting somewhat likely
|
Referent
| |
Referent
| |
Referent
| |
Sitting highly likely
|
0.56 (0.33, 0.94)
|
0.029
|
0.57 (0.36, 0.89)
|
0.013
|
0.89 (0.56, 1.43)
|
0.653
|
BMI (per z-score)
|
1.77 (1.45, 2.18)
|
<0.001
|
1.80 (1.48, 2.19)
|
<0.001
|
1.48 (1.41, 2.22)
|
<0.001
|
p-value for test of interaction
| |
0.292
| |
0.846
| |
0.234
|
Inactive
|
1.00 (0.63, 1.60)
|
0.985
|
0.73 (0.47, 1.13)
|
0.153
|
1.46 (0.87, 2.47)
|
0.154
|
Less active
|
Referent
| |
Referent
| |
Referent
| |
Most active
|
0.99 (0.61, 1.63)
|
0.978
|
0.50 (0.28, 0.91)
|
0.022
|
0.67 (0.37, 1.21)
|
0.184
|
BMI (per z-score)
|
1.85 (1.51, 2.25)
|
<0.001
|
1.82 (1.50, 2.20)
|
<0.001
|
1.84 (1.52, 2.23)
|
<0.001
|
p-value for test of interaction
| |
0.118
| |
0.005
| |
0.414
|
-
OR Odds Ratio, BMI Body Mass Index.
- Note: separate models were examined for each activity exposure and BMI and coefficients reported are from models without a BMIxActivity interaction, adjusting for potential confounders - education at 26y, income at 53y, childhood social class, family history of arthritis, history of knee injury and health status at 53y. Where there was evidence for an interaction, Figures 1C and 1D show the full stratified odds ratios for BMI and activity in these models.