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Table 1 Frequency and percentage of animals with histopathological findings in muscle fiber

From: Muscle wasting associated with pathologic change is a risk factor for the exacerbation of joint swelling in collagen-induced arthritis in cynomolgus monkeys

  Week 2 Week 3 Week 5 Week 9
  (N = 5) (N = 5) (N = 6) (N = 6)
  # % # % # % # %
Necrosis 2 40 1 20 0 0 0 0
Degeneration 1 20 3 60 6 100 5 83
Atrophy 0 0 3 60 4 67 4 67
Regeneration 0 0 0 0 3 50 1 17
  1. #: Number of the animals with the histopathological finding.
  2. %: Percentage of the animals with the histopathological finding
  3. As for degeneration, necrosis, or regeneration of muscle fiber, when a few mass or affected muscle bundles were observed in several scattered areas, the finding was judged positive. Atrophy was diagnosed when width of the muscle bundle was smaller than half width of normal bundle. The number of animals with the above lesions was summarized in Table 1.