Sequential changes of the parameters in the process of arthritis induction. Changes in arthritis score (A), body weight (B), food consumption (C), serum cortisol concentration (D), creatine phosphokinase (E), creatinine (F), C-reactive protein (G), and interleukin-6 (H). Values are expressed as the mean ± SEM. Differences between post- and pre-dosing values were statistically examined using a repeated measures ANOVA model. Statistical differences were evaluated at 5%. N = 22 at pre-immunization and Weeks 1 and 2, N = 17 at Week 3, N = 12 at Weeks 4 and 5, and N = 6 at Weeks 6 to 9. Change in body weight (%) was calculated as the percentage of weight relative to the weight at pre-immunization.