Figure 4

Effects of indomethacin 1 and 10 mg/kg on (A) weight bearing (measured as ratio of light intensity between right hind (RH) and left hind (LH) limbs and (B) ratio of RH/LH print area of mice with complete Freund’s adjuvant (CFA)-induced arthritis. The drugs or their vehicles were administered at 48 hours post-CFA administration and their effects measured at 1, 2 and 3 hours after drug treatment. Each point represents the mean ± S.E.M of the values obtained from 9 to 10 animals. Statistically significant differences in comparison with baseline values: * p < 0.05 and ** p < 0.01 (one-way ANOVA followed by Dunnett's Multiple Comparison Test) and in comparison with drug vehicle treated group at the same time point post treatment: ^# p < 0.05 and ^{# #} p < 0.01 (repeated measures two-way ANOVA followed by Bonferroni post-tests).