Figure 2

Occurrence of morphological changes in focal areas of the muscle tissue. Parts of sections of soleus muscles from a control animal (A), the 1w (B) and 6w (C) groups (exercised side), and the 6w group (D) (non-exercised side), stained with hematoxylin & eosin (H&E). Note that there is a very pronounced inflammatory infiltration and a marked presence of loose connective tissue in (C, D) as compared to in (A). Note also that there are pronounced morphological differences between (A) and (B-D); there are variations in fiber size, and occurrence of fiber splitting (white arrow, D), necrotic fiber (black arrow, B) and frequent internal nuclei (white arrowheads, C, D) in the sections of the experimental animals. Magnification x200 (A, C, D), x100 (B).