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Table 1 Baseline characteristics of all participants

From: Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study

Basic characteristics N = 169
  Female no. (%) * 136 (80 %)
  Age (years) * 62.7 ± 6.3 (49.6-76.5)
  Height (cm) * 166 ± 8 (148–191)
  Weight (kg) * 102.3 ± 14.6 (76.0-145.0)
  BMI (kg/m2) * 37.0 ± 4.5 (30.1-51.6)
  C-reactive protein (mg/L) 1 § 4.1 [2.2;7.3] (0.7-58.6)
Isometric maximal voluntary contraction  
  Quadriceps Muscle Strength (nm/kg) 1, 2 + 1.1 [0.9;1.4] (0.1-2.8)
  Hamstrings Muscle Strength (nm/kg) 1, 2 + 0.5 [0.4;0.6] (0.0-1.1)
Radiographs  
  KL whole joint score (0–4) 1, 3 * 3.0 [2.0;3.0] (1.0 – 4.0)
  KL medial tibiofemoral joint (0–4) 1, 3 * 2.0 [2.0;3.0] (0.0 – 4.0)
  KL lateral tibiofemoral joint (0–4) 1, 3 * 2.0 [1.0;2.0] (0.0 – 4.0)
  KL patellofemoral joint (0–4) 1, 3 * 2.0 [1.0;3.0] (0.0 – 4.0)
  mJSW 1, 4 ^ 2.2 [0.00;3.8] (0.0 – 7.3)
MRI  
  Bone Marrow Lesions sum of size scores 1, 5 * 3.0 [1.0;5.0] (0.0-9.0)
  Cartilage I combo score(0–81) 1, 6 * 15.0 [6.0;27.0] (0.0-61.0)
  Osteophytes sum of scores (0–36) 1 * 13.0 [8.0;18.0] (1.0-35.0)
  Menisci sum of extrusion scores (0–12) 1 * 7.0 [5.0;9.0] (0.0-12.0)
  Menisci sum of morphology scores (0–38) 1 * 7.0 [6.0;8.0] (0.0-11.0)
Symptomatic assessment  
  KOOS Function in daily living (ADL) * 60.4 ± 16.6 (11.8 – 98.5)
  KOOS Pain * 57.4 ± 15.9 (11.1 – 100)
Knee joint alignment axis 7  
  Varus (>0) / Valgus (<0) º 6.0 ± 4.8 (-8.6 – 23.7)
  1. Plus-minus values are means ± SD and (min-max) unless otherwise stated.
  2. 1 Presented as median, interquartile range [Q1;Q3] and (min – max).
  3. 2 Measured isometric at 60 ° and normalized to body weight (nm/kg).
  4. 3 Scored using the Kellgren & Lawrence Grading system.
  5. 4 mJSW; minimum Joint Space Width (mm).
  6. 5 Sum of all BML size scores except those from patella.
  7. 6 For all analyzed areas we multiplied the “surface area”-score (0–3) with the “full thickness”-score (0–3), reaching results between 0 and 9 for each area, and then multiplied them into one “combo score” reaching a final score between 0 and 81.
  8. 7 From the static anatomical landmark calibration trials for each subject the knee joint mechanical axis alignment was calculated using a Plug-In-Gait model.
  9. Number of participants included in analysis varied due to missing data for specific variables, as follows: * 169 patients; + 164 patients; ^ 152 patients; º 158 patients; § 162 patients.