Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

Ahmad Omair; Marit Holden; Benedicte Alexandra Lie; Olav Reikeras; Jens Ivar Brox

doi:10.1186/1471-2474-14-105

BMC Musculoskeletal Disorders

Table 3 Characteristics of the patients ( N =93) carrying different genotypes for the associated SNPs

From: Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

	IL18RAP(rs1420106)			IL18RAP(rs917997)			MMP3(rs72520913)
Genotype	A/A	A/G	G/G	T/T	C/T	C/C	A/A	A/C	C/C
Number of Patients	7	33	53	7	36	50	18	56	19
Males / Females	2/5	10/23	23/30	2/5	11/25	22/28	8/10	19/37	8/11
Age at follow-up	49.9 [9.1]	49.3 [12.9]	53.8 [7.3]	49.9 [9.1]	49.8 [8.2]	53.7 [7.4]	51.6 [8.7]	53.2 [6.7]	48.4 [10.0]
Mean [SD]	49.9 [9.1]	49.3 [12.9]	53.8 [7.3]	49.9 [9.1]	49.8 [8.2]	53.7 [7.4]	51.6 [8.7]	53.2 [6.7]	48.4 [10.0]
Fusion/cognitive	5/2	23/10	32/21	5/2	24/12	31/19	10/8	39/17	11/8
Baseline ODI	43.1 [8.9]	47.6 [12.9]	42.0 [9.6]	43.1 [8.9]	46.5 [18.2]	42.5 [9.6]	40.3 [10.0]	45.1 [11.0]	44.6 [11.8]
Mean [SD]	43.1 [8.9]	47.6 [12.9]	42.0 [9.6]	43.1 [8.9]	46.5 [18.2]	42.5 [9.6]	40.3 [10.0]	45.1 [11.0]	44.6 [11.8]
Follow-up ODI	41.1 [20.6]	23.9 [18.5]	21.9 [17.6]	41.1 [20.6]	25.1 [18.2]	21.0 [17.6]	25.2 [14.1]	24.6 [19.6]	21.3 [19.8]
Mean [SD]	41.1 [20.6]	23.9 [18.5]	21.9 [17.6]	41.1 [20.6]	25.1 [18.2]	21.0 [17.6]	25.2 [14.1]	24.6 [19.6]	21.3 [19.8]
ODI change	- 2 [17.8]	- 23.8 [20.8]	- 20.0 [20.8]	- 2 [17.8]	- 21.4 [21.5]	- 21.5 [19.6]	- 15.2 [16.3]	- 20.4 [22.0]	- 23.3 [20.8]
Mean [SD]	- 2 [17.8]	- 23.8 [20.8]	- 20.0 [20.8]	- 2 [17.8]	- 21.4 [21.5]	- 21.5 [19.6]	- 15.2 [16.3]	- 20.4 [22.0]	- 23.3 [20.8]
Baseline VAS LBP	56.5 [14.2]	64.5 [13.3]	61.9 [13.7]	56.5 [14.2]	63.7 [13.1]	62.3 [14.0]	59.5 [11.7]	62.5 [13.5]	64.7 [15.9]
Mean [SD]	56.5 [14.2]	64.5 [13.3]	61.9 [13.7]	56.5 [14.2]	63.7 [13.1]	62.3 [14.0]	59.5 [11.7]	62.5 [13.5]	64.7 [15.9]
Follow-up VAS LBP	48.8 [23.2]	38.4 [25.3]	36.0 [25.8]	48.8 [23.2]	39.1 [24.5]	35.3 [26.3]	48.7 [20.0]	33.8 [25.6]	39.2 [27.5]
Mean [SD]	48.8 [23.2]	38.4 [25.3]	36.0 [25.8]	48.8 [23.2]	39.1 [24.5]	35.3 [26.3]	48.7 [20.0]	33.8 [25.6]	39.2 [27.5]
VAS LBP change	- 7.7 [24.3]	- 26.1 [25.8]	- 25.9 [32.9]	- 7.7 [24.3]	- 24.6 [25.3]	- 27.0 [33.5]	- 10.8 [18.5]	- 28.7 [33.2]	- 25.5 [26.2]
Mean [SD]	- 7.7 [24.3]	- 26.1 [25.8]	- 25.9 [32.9]	- 7.7 [24.3]	- 24.6 [25.3]	- 27.0 [33.5]	- 10.8 [18.5]	- 28.7 [33.2]	- 25.5 [26.2]

Worst possible score for ODI and VAS LBP was 100.

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