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Table 3 Characteristics of the patients ( N =93) carrying different genotypes for the associated SNPs

From: Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

  IL18RAP(rs1420106) IL18RAP(rs917997) MMP3(rs72520913)
Genotype A/A A/G G/G T/T C/T C/C A/A A/C C/C
Number of Patients 7 33 53 7 36 50 18 56 19
Males / Females 2/5 10/23 23/30 2/5 11/25 22/28 8/10 19/37 8/11
Age at follow-up 49.9 [9.1] 49.3 [12.9] 53.8 [7.3] 49.9 [9.1] 49.8 [8.2] 53.7 [7.4] 51.6 [8.7] 53.2 [6.7] 48.4 [10.0]
Mean [SD]
Fusion/cognitive 5/2 23/10 32/21 5/2 24/12 31/19 10/8 39/17 11/8
Baseline ODI 43.1 [8.9] 47.6 [12.9] 42.0 [9.6] 43.1 [8.9] 46.5 [18.2] 42.5 [9.6] 40.3 [10.0] 45.1 [11.0] 44.6 [11.8]
Mean [SD]
Follow-up ODI 41.1 [20.6] 23.9 [18.5] 21.9 [17.6] 41.1 [20.6] 25.1 [18.2] 21.0 [17.6] 25.2 [14.1] 24.6 [19.6] 21.3 [19.8]
Mean [SD]
ODI change - 2 [17.8] - 23.8 [20.8] - 20.0 [20.8] - 2 [17.8] - 21.4 [21.5] - 21.5 [19.6] - 15.2 [16.3] - 20.4 [22.0] - 23.3 [20.8]
Mean [SD]
Baseline VAS LBP 56.5 [14.2] 64.5 [13.3] 61.9 [13.7] 56.5 [14.2] 63.7 [13.1] 62.3 [14.0] 59.5 [11.7] 62.5 [13.5] 64.7 [15.9]
Mean [SD]
Follow-up VAS LBP 48.8 [23.2] 38.4 [25.3] 36.0 [25.8] 48.8 [23.2] 39.1 [24.5] 35.3 [26.3] 48.7 [20.0] 33.8 [25.6] 39.2 [27.5]
Mean [SD]
VAS LBP change - 7.7 [24.3] - 26.1 [25.8] - 25.9 [32.9] - 7.7 [24.3] - 24.6 [25.3] - 27.0 [33.5] - 10.8 [18.5] - 28.7 [33.2] - 25.5 [26.2]
Mean [SD]
  1. Worst possible score for ODI and VAS LBP was 100.