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Table 2 Association analysis of inflammatory and matrix degrading gene polymorphisms with 9 years ODI change and VAS LBP change in 93 patients with LDD and LBP

From: Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

   

ODI change

VAS LBP change

SNP*

Gene

Recessive genotype

Mean difference (β) † (95% CI)∞

p value

Mean difference (β) (95% CI)

p value

rs2071375

IL1A

T/T

8.8 (-8.3 - 26)

0.31

11.3 (-11.3 - 33.9)

0.32

rs2287037

IL18R1

T/T

6.8 (-8.6 – 22.2)

0.38

11.0 (-9.3 - 11)

0.29

rs1420100

IL18RAP

A/A

6.1 (-4 – 16.2)

0.23

5.1 (-8.3 – 18.5)

0.45

rs1420106

IL18RAP

A/A

19.4 (3.9 - 35)

0.02

18.4 (-2.5 – 39.3)

0.08

rs917997

IL18RAP

T/T

19.4 (3.9 - 35)

0.02

18.4 (-2.5 – 39.3)

0.08

rs5277

COX2§

G/G

15.0 (-5.8 – 35.8)

0.16

24.4 (-2.8 – 51.6)

0.08

rs72520913

MMP3

A/A

5.0 (-5.7 – 15.7)

0.36

15.6 (1.8 – 29.4)

0.03

  1. * Single nucleotide polymorphism; † mean difference in pain and disability scores for two rare alleles; ∞ 95% confidence interval.
  2. § COX2 SNP rs4140564 was left out of the analysis due to no G/G genotype in the cohort.