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Table 2 Association analysis of inflammatory and matrix degrading gene polymorphisms with 9 years ODI change and VAS LBP change in 93 patients with LDD and LBP

From: Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

    ODI change VAS LBP change
SNP* Gene Recessive genotype Mean difference (β) † (95% CI)∞ p value Mean difference (β) (95% CI) p value
rs2071375 IL1A T/T 8.8 (-8.3 - 26) 0.31 11.3 (-11.3 - 33.9) 0.32
rs2287037 IL18R1 T/T 6.8 (-8.6 – 22.2) 0.38 11.0 (-9.3 - 11) 0.29
rs1420100 IL18RAP A/A 6.1 (-4 – 16.2) 0.23 5.1 (-8.3 – 18.5) 0.45
rs1420106 IL18RAP A/A 19.4 (3.9 - 35) 0.02 18.4 (-2.5 – 39.3) 0.08
rs917997 IL18RAP T/T 19.4 (3.9 - 35) 0.02 18.4 (-2.5 – 39.3) 0.08
rs5277 COX2§ G/G 15.0 (-5.8 – 35.8) 0.16 24.4 (-2.8 – 51.6) 0.08
rs72520913 MMP3 A/A 5.0 (-5.7 – 15.7) 0.36 15.6 (1.8 – 29.4) 0.03
  1. * Single nucleotide polymorphism; † mean difference in pain and disability scores for two rare alleles; ∞ 95% confidence interval.
  2. § COX2 SNP rs4140564 was left out of the analysis due to no G/G genotype in the cohort.